110977-75-8Relevant academic research and scientific papers
Indoles X: Synthesis, structure and D2-affinity of the β-carboline-analogue of flutroline
Lehmann,Knoch,Jiang
, p. 947 - 951 (2007/10/02)
10 is a β-carboline analogue of the neuroleptic flutroline(2a,b)) with significant lower affinity at the dopamine D2 binding site. Various synthetic routes to 10 and the solid state structure of 8 are described, structure activity relations, in particular the importance of the 'S-shape' and the rigid dopamine conformation are discussed.
Lactones, XI: Syntheses of 4,9-Dihydropyrano-indol-1(3H)-ones from &α-Ethoxalyl-&γ-lactones
Lehmann, Jochen,Ghoneim, Khadiga M.,El-Fattah, Bothaina Abd,El-Gendy, Adel A.
, p. 22 - 29 (2007/10/02)
Cleavage and decarboxylation of the α-ethoxalyl-γ-lactones 1a-d followed by treatment with phenylhydrazines yield the hydrazones 4a-l, which can be rearranged to the indololactones 5a-m.Starting from the δ-lactones 6 and 10, the same reactions lead to indoles without lactone ring closure.
