(3S)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one

Base Information

• Chemical Name: (3S)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one
• CAS No.: 73534-55-1
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.191
• Mol file: 73534-55-1.mol

Synonyms:(3S)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one

Chemical Property of (3S)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one

Chemical Property:

• Melting Point: 112.4 °C
• Boiling Point: 360.4±31.0 °C(Predicted)
• Density: 1.119±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(S)-3-Methyl-3,4-dihydroquinoxalin-2(1H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one

There total 12 articles about (3S)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2S)-2-(2-nitrophenylamino)propionic acid methyl ester → (3S)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one (73534-55-1)

Guidance literature:

With iron; ammonium chloride; In water; ethyl acetate; at 22 ℃;

DOI:10.1002/ejoc.201801639

Reference yield: 90.0%

2-[(2-nitrophenyl)amino]propanoic acid → (3S)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one (73534-55-1)

Guidance literature:

2-[(2-nitrophenyl)amino]propanoic acid; With hydrogenchloride; tin(ll) chloride; In ethanol; for 2h; Reflux;

With potassium carbonate; In water;

DOI:10.1016/j.ejmech.2019.111987

Reference yield: 74.0%

L-alanin (56-41-7,25191-17-7,18875-37-1) + 2-bromoaniline (615-36-1) → (3S)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one (73534-55-1)

Guidance literature:

With potassium phosphate; copper(l) chloride; N,N`-dimethylethylenediamine; In dimethyl sulfoxide; at 110 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201000323

upstream raw materials:

1,2-diamino-benzene

1,2:5,6-di-O-isopropylidene-α-D-glucofuranos-3-O-yl α-bromopropionate

ortho-nitrofluorobenzene

(2-methoxy-2-oxo-(S)-1-phenylethyl) α-bromopropanoate

Downstream raw materials:

3-methyl-2-oxo-1,2-dihydroquinoxaline