(+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>hypoxanthine

Base Information

Chemical Name:(+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>hypoxanthine
CAS No.:145440-07-9
Molecular Formula:C₂₅H₂₈N₄O₄Si
Molecular Weight:476.607
Hs Code.:

Synonyms:(+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>hypoxanthine

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Chemical Property of (+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>hypoxanthine

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Technology Process of (+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>hypoxanthine

There total 4 articles about (+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>hypoxanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 145439-99-2
(+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-6-chloropurine

: 145440-07-9
(+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>hypoxanthine

Guidance literature:: With sodium methylate; 2-hydroxyethanethiol; In methanol; for 1.5h; Heating;
DOI:10.1021/jm00053a004

Reference yield:

: 32865-86-4
6-chloro-9-trimethylsilylpurine

: 145440-07-9
(+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>hypoxanthine

Guidance literature:: Multi-step reaction with 2 steps

1: TMSOTf / CH₂Cl₂ / a) RT, 30 min, b) reflux, 14 h

2: 99 percent / 2-mercaptoethanol, NaOMe / methanol / 1.5 h / Heating

With trimethylsilyl trifluoromethanesulfonate; sodium methylate; 2-hydroxyethanethiol; In methanol; dichloromethane;
DOI:10.1021/jm00053a004

Reference yield:

: 229635-18-1
(2R)-4-acetoxy-2-<<(tert-butyldiphenylsilyl)oxy>methyl>dioxolane

: 145440-07-9
(+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>hypoxanthine

Guidance literature:: Multi-step reaction with 2 steps

1: TMSOTf / CH₂Cl₂ / a) RT, 30 min, b) reflux, 14 h

2: 99 percent / 2-mercaptoethanol, NaOMe / methanol / 1.5 h / Heating

With trimethylsilyl trifluoromethanesulfonate; sodium methylate; 2-hydroxyethanethiol; In methanol; dichloromethane;
DOI:10.1021/jm00053a004