N-{4-(hydroxymethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-{4-(hydroxymethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide
CAS No.:1318754-60-7
Molecular Formula:C₁₇H₁₅F₃N₄O₂S
Molecular Weight:396.393
Hs Code.:

Synonyms:N-{4-(hydroxymethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

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Chemical Property of N-{4-(hydroxymethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

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Technology Process of N-{4-(hydroxymethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

There total 5 articles about N-{4-(hydroxymethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1318754-59-4
ethyl 5-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-2-[3-(trifluoromethyl)benzyl]-1,3-thiazole-4-carboxylate

: 1318754-60-7
N-{4-(hydroxymethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at 0 - 20 ℃;

Reference yield:

: 2003-14-7
(3-trifluoromethyl-phenyl)-acetyl chloride

: 1318754-60-7
N-{4-(hydroxymethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate; sodium dithionite / water / 2 h / 20 °C

1.2: 0 - 20 °C

2.1: Lawessons reagent / toluene / 6 h / 80 °C

3.1: N,N-dimethyl acetamide / 3 h / 80 °C

4.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 0 - 20 °C

With Lawessons reagent; sodium dithionite; diisobutylaluminium hydride; sodium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl acetamide; water; toluene;

Reference yield:

: 84547-59-1
2-methyl-2H-pyrazole-3-carbonyl chloride

: 1318754-60-7
N-{4-(hydroxymethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl acetamide / 3 h / 80 °C

2: diisobutylaluminium hydride / toluene; tetrahydrofuran / 0 - 20 °C

With diisobutylaluminium hydride; In tetrahydrofuran; N,N-dimethyl acetamide; toluene;