Technology Process of (S)-8-(4-Methoxy-benzyloxymethyl)-2,2,6,6-tetramethyl-1,3-dioxa-spiro[4.5]dec-7-ene
There total 10 articles about (S)-8-(4-Methoxy-benzyloxymethyl)-2,2,6,6-tetramethyl-1,3-dioxa-spiro[4.5]dec-7-ene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 60 ℃;
for 5h;
DOI:10.1016/j.tetlet.2004.09.143
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 96 percent / imidazole / CH2Cl2 / 1.5 h
2.1: 50 percent / SmI2; HMPA / tetrahydrofuran / 0.25 h / -78 °C
3.1: aq. H2O2; KHCO3; KF / tetrahydrofuran; methanol / 10 h
4.1: CSA / 1 h
5.1: 97 percent / Dess-Martin periodinane / CH2Cl2 / 2 h
6.1: LDA; Eschenmoser's salt / tetrahydrofuran / 1 h / -78 - 0 °C
6.2: 64 percent / acetone / 10 h
7.1: 96 percent / NaBH4 / CeCl3*7H2O / methanol / 0.08 h
8.1: 84 percent / SOCl2; pyridine / diethyl ether / 3 h
9.1: 92 percent / TBAI / tetrahydrofuran; dimethylformamide / 5 h / 60 °C
With
pyridine; 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium fluoride; sodium tetrahydroborate; thionyl chloride; samarium diiodide; dihydrogen peroxide; eschenmoser's salt; tetra-(n-butyl)ammonium iodide; potassium hydrogencarbonate; Dess-Martin periodane; lithium diisopropyl amide;
cerium(III) chloride; camphor-10-sulfonic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
3.1: Tamao oxidation / 5.1: Dess-Martin oxidation / 7.1: Luche reduction;
DOI:10.1016/j.tetlet.2004.09.143
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: CSA / 1 h
2.1: 97 percent / Dess-Martin periodinane / CH2Cl2 / 2 h
3.1: LDA; Eschenmoser's salt / tetrahydrofuran / 1 h / -78 - 0 °C
3.2: 64 percent / acetone / 10 h
4.1: 96 percent / NaBH4 / CeCl3*7H2O / methanol / 0.08 h
5.1: 84 percent / SOCl2; pyridine / diethyl ether / 3 h
6.1: 92 percent / TBAI / tetrahydrofuran; dimethylformamide / 5 h / 60 °C
With
pyridine; sodium tetrahydroborate; thionyl chloride; eschenmoser's salt; tetra-(n-butyl)ammonium iodide; Dess-Martin periodane; lithium diisopropyl amide;
cerium(III) chloride; camphor-10-sulfonic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
2.1: Dess-Martin oxidation / 4.1: Luche reduction;
DOI:10.1016/j.tetlet.2004.09.143
