6-chloro-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

Base Information

Chemical Name:6-chloro-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one
CAS No.:1332697-06-9
Molecular Formula:C₂₀H₂₀ClNO₂
Molecular Weight:341.837
Hs Code.:

Synonyms:6-chloro-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

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Chemical Property of 6-chloro-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

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Technology Process of 6-chloro-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

There total 8 articles about 6-chloro-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₁₇Cl₂NO₂

: 1332697-06-9
6-chloro-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

Guidance literature:: C₂₀H₁₇Cl₂NO₂; With sodium tetrahydroborate; In tetrahydrofuran; 1,2-dimethoxyethane; at 0 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; 1,2-dimethoxyethane; water;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₂₁H₁₉ClO₇

: 1332697-06-9
6-chloro-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; water; acetic acid / 3 h / 110 °C

2: methanol / 15 h / 20 °C

3: hydrogenchloride / ethyl acetate / 3 h / 20 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

5: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 2 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; water; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethyl acetate;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₂₀H₂₀ClNO₄

: 1332697-06-9
6-chloro-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 2 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; ethyl acetate;
DOI:10.1016/j.bmc.2011.06.059