2-(2-fluoro-3-trifluoromethyl-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclobutylmethyl-amide

Base Information

Chemical Name:2-(2-fluoro-3-trifluoromethyl-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclobutylmethyl-amide
CAS No.:666263-13-4
Molecular Formula:C₁₈H₁₅F₇N₄O
Molecular Weight:436.332
Hs Code.:

Synonyms:2-(2-fluoro-3-trifluoromethyl-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclobutylmethyl-amide

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Chemical Property of 2-(2-fluoro-3-trifluoromethyl-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclobutylmethyl-amide

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Technology Process of 2-(2-fluoro-3-trifluoromethyl-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclobutylmethyl-amide

There total 4 articles about 2-(2-fluoro-3-trifluoromethyl-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclobutylmethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 666262-52-8
2-chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (cyclobutylmethyl)-amide

: 123973-25-1
2-fluoro-3-(trifluoromethyl)aniline

: 666263-13-4
2-(2-fluoro-3-trifluoromethyl-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclobutylmethyl-amide

Guidance literature:: at 180 ℃; for 0.5h; Irradiation;

Reference yield:

: 4426-11-3
cyclobutanecarbonitrile

: 666263-13-4
2-(2-fluoro-3-trifluoromethyl-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclobutylmethyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / Heating / reflux

1.2: 0.75 h / 0 - 25 °C

1.3: 1.5 h / Heating / reflux

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -30 - 20 °C

3.1: 0.5 h / 180 °C / Microwave irradiation

With borane-THF; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 154934-99-3
2-chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl chloride

: 666263-13-4
2-(2-fluoro-3-trifluoromethyl-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclobutylmethyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -30 - 20 °C

2: 0.5 h / 180 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; In dichloromethane;