3-[(2S)-1-[(2S)-2-cyclopropyl-2-hydroxyethanoyl]-4-(2,5-difluorophenyl)-2,5-dihydro-1H-pyrrol-2-yl]phenol

Base Information

Chemical Name:3-[(2S)-1-[(2S)-2-cyclopropyl-2-hydroxyethanoyl]-4-(2,5-difluorophenyl)-2,5-dihydro-1H-pyrrol-2-yl]phenol
CAS No.:639074-94-5
Molecular Formula:C₂₁H₁₉F₂NO₃
Molecular Weight:371.384
Hs Code.:

Synonyms:3-[(2S)-1-[(2S)-2-cyclopropyl-2-hydroxyethanoyl]-4-(2,5-difluorophenyl)-2,5-dihydro-1H-pyrrol-2-yl]phenol

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Chemical Property of 3-[(2S)-1-[(2S)-2-cyclopropyl-2-hydroxyethanoyl]-4-(2,5-difluorophenyl)-2,5-dihydro-1H-pyrrol-2-yl]phenol

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Technology Process of 3-[(2S)-1-[(2S)-2-cyclopropyl-2-hydroxyethanoyl]-4-(2,5-difluorophenyl)-2,5-dihydro-1H-pyrrol-2-yl]phenol

There total 7 articles about 3-[(2S)-1-[(2S)-2-cyclopropyl-2-hydroxyethanoyl]-4-(2,5-difluorophenyl)-2,5-dihydro-1H-pyrrol-2-yl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (S)-1-[(S)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-pyrrol-1-yl]-2-cyclopropyl-2-hydroxy-ethanone

: 639074-94-5
3-[(2S)-1-[(2S)-2-cyclopropyl-2-hydroxyethanoyl]-4-(2,5-difluorophenyl)-2,5-dihydro-1H-pyrrol-2-yl]phenol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.12.094

Reference yield:

: 635724-41-3
tert-butyl 3-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

: 639074-94-5
3-[(2S)-1-[(2S)-2-cyclopropyl-2-hydroxyethanoyl]-4-(2,5-difluorophenyl)-2,5-dihydro-1H-pyrrol-2-yl]phenol

Guidance literature:: Multi-step reaction with 4 steps

1: Pd(OAc)2; Ph₃As / 0.5 h / 150 °C / microwave irradiation

2: 95 percent / TFA / CH₂Cl₂

3: PyBOP; Et₃N / dimethylformamide

4: 90 percent / K₂CO₃ / dimethylformamide

With palladium diacetate; triphenyl-arsane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Heck coupling;
DOI:10.1016/j.bmcl.2005.12.094

Reference yield:

: 884651-22-3
2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrole

: 639074-94-5
3-[(2S)-1-[(2S)-2-cyclopropyl-2-hydroxyethanoyl]-4-(2,5-difluorophenyl)-2,5-dihydro-1H-pyrrol-2-yl]phenol

Guidance literature:: Multi-step reaction with 2 steps

1: PyBOP; Et₃N / dimethylformamide

2: 90 percent / K₂CO₃ / dimethylformamide

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.12.094