Phosphoric acid dibenzyl ester 3-[(S)-1-((S)-2-cyclopropyl-2-hydroxy-acetyl)-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

Base Information

Chemical Name:Phosphoric acid dibenzyl ester 3-[(S)-1-((S)-2-cyclopropyl-2-hydroxy-acetyl)-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester
CAS No.:884651-23-4
Molecular Formula:C₃₅H₃₂F₂NO₆P
Molecular Weight:631.613
Hs Code.:

Synonyms:Phosphoric acid dibenzyl ester 3-[(S)-1-((S)-2-cyclopropyl-2-hydroxy-acetyl)-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

Suppliers and Price of Phosphoric acid dibenzyl ester 3-[(S)-1-((S)-2-cyclopropyl-2-hydroxy-acetyl)-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Phosphoric acid dibenzyl ester 3-[(S)-1-((S)-2-cyclopropyl-2-hydroxy-acetyl)-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Phosphoric acid dibenzyl ester 3-[(S)-1-((S)-2-cyclopropyl-2-hydroxy-acetyl)-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

There total 7 articles about Phosphoric acid dibenzyl ester 3-[(S)-1-((S)-2-cyclopropyl-2-hydroxy-acetyl)-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 639074-94-5
3-[(2S)-1-[(2S)-2-cyclopropyl-2-hydroxyethanoyl]-4-(2,5-difluorophenyl)-2,5-dihydro-1H-pyrrol-2-yl]phenol

: 17176-77-1
Dibenzyl phosphite

: 884651-23-4
Phosphoric acid dibenzyl ester 3-[(S)-1-((S)-2-cyclopropyl-2-hydroxy-acetyl)-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

Guidance literature:: With tetrachloromethane; dmap; N,N-diethyl-N-isopropylamine; In acetonitrile; at 0 - 25 ℃;
DOI:10.1016/j.bmcl.2005.12.094

Reference yield:

: 635724-41-3
tert-butyl 3-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

: 884651-23-4
Phosphoric acid dibenzyl ester 3-[(S)-1-((S)-2-cyclopropyl-2-hydroxy-acetyl)-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Pd(OAc)2; Ph₃As / 0.5 h / 150 °C / microwave irradiation

2: 95 percent / TFA / CH₂Cl₂

3: PyBOP; Et₃N / dimethylformamide

4: 90 percent / K₂CO₃ / dimethylformamide

5: 82 percent / i-PrNEt₂; DMAP; CCl₄ / acetonitrile / 0 - 25 °C

With tetrachloromethane; dmap; palladium diacetate; N,N-diethyl-N-isopropylamine; triphenyl-arsane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: Heck coupling;
DOI:10.1016/j.bmcl.2005.12.094

Reference yield:

: 884651-22-3
2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrole

: 884651-23-4
Phosphoric acid dibenzyl ester 3-[(S)-1-((S)-2-cyclopropyl-2-hydroxy-acetyl)-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: PyBOP; Et₃N / dimethylformamide

2: 90 percent / K₂CO₃ / dimethylformamide

3: 82 percent / i-PrNEt₂; DMAP; CCl₄ / acetonitrile / 0 - 25 °C

With tetrachloromethane; dmap; N,N-diethyl-N-isopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.12.094