TETRAETHYL(4-AMINOBUTYLIDENE)BISPHOSPHONATE

Base Information

• Chemical Name: TETRAETHYL(4-AMINOBUTYLIDENE)BISPHOSPHONATE
• CAS No.: 90315-14-3
• Molecular Formula: C₁₂H₂₉NO₆P₂
• Molecular Weight: 345.313
• Hs Code.: 2922499990
• Mol file: 90315-14-3.mol

Synonyms:TETRAETHYL(4-AMINOBUTYLIDENE)BISPHOSPHONATE;Tetraethyl(4-aminobutyllidene)bisphosphonate;Tetraethyl(4-aminobutylidene)bisphosphonate, min. 85 % (31P-NMR)

Chemical Property of TETRAETHYL(4-AMINOBUTYLIDENE)BISPHOSPHONATE

Chemical Property:

• PSA: 116.70000
• LogP: 4.28390

Purity/Quality:

97% ^*data from raw suppliers

TETRAETHYL(4-AMINOBUTYLIDENE)BISPHOSPHONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TETRAETHYL(4-AMINOBUTYLIDENE)BISPHOSPHONATE

There total 4 articles about TETRAETHYL(4-AMINOBUTYLIDENE)BISPHOSPHONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[4-azido-1-(diethoxy-phosphoryl)-butyl]-phosphonic acid diethyl ester (273936-66-6) → tetraethyl 4-aminobutylidene-1,1-bisphosphonate (90315-14-3)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; for 12h;

DOI:10.1080/10426509808036988

Reference yield:

tetraethyl 4-hydroxybutylene-1,1-bisphosphonate (150250-34-3) → tetraethyl 4-aminobutylidene-1,1-bisphosphonate (90315-14-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: 80 percent / NaN₃ / dimethylformamide / 12 h / Ambient temperature

3: Ph₃P, H₂O / tetrahydrofuran / 12 h

With sodium azide; water; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1080/10426509808036988

Reference yield:

[(EtO)2P(O)]2CH(CH2)3OMs (273936-62-2) → tetraethyl 4-aminobutylidene-1,1-bisphosphonate (90315-14-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NaN₃ / dimethylformamide / 12 h / Ambient temperature

2: Ph₃P, H₂O / tetrahydrofuran / 12 h

With sodium azide; water; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1080/10426509808036988

upstream raw materials:

[4-azido-1-(diethoxy-phosphoryl)-butyl]-phosphonic acid diethyl ester

tetraethyl 4-hydroxybutylene-1,1-bisphosphonate

[(EtO)2P(O)]2CH(CH₂)3OMs

tetraethyl 4-(tetrahydro-2H-pyran-2-yloxy)butylene-1,1-bisphosphonate

Refernces