150250-34-3

Basic information

• Product Name: TETRAETHYL(4-HYDROXYBUTYLIDENE)BISPHOSPHONATE
• Synonyms: TETRAETHYL(4-HYDROXYBUTYLIDENE)BISPHOSPHONATE;Tetraethyl(4-hydroxybutyllidene)bisphosphonate;Tetraethyl(4-hydroxybutylidene)bisphosphonate, tech (min 70 %);4,4-Bis(Diethoxyphosphoryl)butan-1-ol
• CAS NO: 150250-34-3
• Molecular Formula: C₁₂H₂₈O₇P₂
• Molecular Weight: 346.29
• Mol File: 150250-34-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 449.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.161±0.06 g/cm3(Predicted)
• PKA: 14.97±0.10(Predicted)
• CAS DataBase Reference: TETRAETHYL(4-HYDROXYBUTYLIDENE)BISPHOSPHONATE(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAETHYL(4-HYDROXYBUTYLIDENE)BISPHOSPHONATE(150250-34-3)
• EPA Substance Registry System: TETRAETHYL(4-HYDROXYBUTYLIDENE)BISPHOSPHONATE(150250-34-3)

Safety Data

• Hazardous Substances Data: 150250-34-3(Hazardous Substances Data)

Upstream product

• 1660-94-2 Tetraethyl methylenediphosphonate 
• 150250-33-2 tetraethyl 4-(tetrahydro-2H-pyran-2-yloxy)butylene-1,1-bisphosphonate 
• 126146-27-8 tetraethyl but-3-enylidene-1,1-bisphosphonate 

Downstream Products

• 150250-35-4 [(EtO)2P(O)]2CH(CH₂)3OTs 
• 159275-20-4 tetraethyl 4-phenoxycarbonyloxybutylidene-1,1-diphosphonate 
• 925684-97-5 1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-(3-(4-(4,4-bis(diethylphosphono)butoxy)phenyl)-3-oxopropyl)-3-methylpiperazin-1-yl)-8-methoxy-4-oxoquinoline-3-carboxylic acid 
• 947537-33-9 C₆₇H₉₆N₄O₁₉P₂ 
• 925684-96-4 1-(4-(4,4-bis(diethylphosphono)butoxy)phenyl)prop-2-en-1-one 
• 1208103-62-1 tert-butyl N-(9-fluorenylmethoxycarbonyl)-O-(4,4-bis(diethylphosphono)butyl)-L-tyrosine 
• 136496-88-3 tetraethyl 3-carboxypropylene-1,1-bisphosphonate 
• 90315-14-3 tetraethyl 4-aminobutylidene-1,1-bisphosphonate 

Relevant articles and documents

PHOSPHONATED RIFAMYCINS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS

The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and joint infections, especially for the prophylaxis and/or treatment of osteomyelitis.

PHOSPHONATED RIFAMYCINS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS

The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and joint infections, especially for the prophylaxis and/or treatment of osteomyelitis.

Bisphosphonated fluoroquinolone esters as osteotropic prodrugs for the prevention of osteomyelitis

Osteomyelitis is a difficult to treat bacterial infection of the bone. Delivering antibacterial agents to the bone may overcome the difficulties in treating this illness by effectively concentrating the antibiotic at the site of infection and by limiting the toxicity that may result from systemic exposure to the large doses conventionally used. Using bisphosphonates as osteophilic functional groups, different forms of fluoroquinolone esters were synthesized and evaluated for their ability to bind bone and to release the parent antibacterial agent. Bisphosphonated glycolamide fluoroquinolone esters were found to present a profile consistent with effective and rapid bone binding and efficient release of the active drug moiety. They were assessed for their ability to prevent bone infection in vivo and were found to be effective when the free fluoroquinolones were not.