1-acetoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-4-phenyl-2-butanone

Base Information

• Chemical Name: 1-acetoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-4-phenyl-2-butanone
• CAS No.: 319914-34-6
• Molecular Formula: C₁₇H₂₃NO₅
• Molecular Weight: 321.373
• Mol file: 319914-34-6.mol

Synonyms:1-acetoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-4-phenyl-2-butanone

Chemical Property of 1-acetoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-4-phenyl-2-butanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-acetoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-4-phenyl-2-butanone

There total 1 articles about 1-acetoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-4-phenyl-2-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

potassium acetate (127-08-2) + (S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate (102123-74-0) → 1-acetoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-4-phenyl-2-butanone (319914-34-6)

Guidance literature:

With sodium iodide; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1016/0957-4166(96)00124-3

Reference yield: 72.0%

1-acetoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-4-phenyl-2-butanone (319914-34-6) → 1-hydroxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-4-phenyl-2-butanone (134558-29-5)

Guidance literature:

With potassium carbonate; In methanol; for 3.5h;

DOI:10.1016/0957-4166(96)00124-3

Reference yield:

1-acetoxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-4-phenyl-2-butanone (319914-34-6) → ((1S,2R)-1-benzyl-2,3-dihydroxypropyl)carbamic acid tert-butyl ester (99113-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / aq. K₂CO₃ / methanol / 3.5 h

2: NaBH₄ / tetrahydrofuran; methanol / 1 h / 0 °C

With sodium tetrahydroborate; potassium carbonate; In tetrahydrofuran; methanol;

DOI:10.1016/0957-4166(96)00124-3

upstream raw materials:

potassium acetate

(S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate

Downstream raw materials:

1-hydroxy-3-<<(1,1-dimethylethoxy)carbonyl>amino>-4-phenyl-2-butanone

((1S,2R)-1-benzyl-2,3-dihydroxypropyl)carbamic acid tert-butyl ester

(2S,3S)-3-(t-butoxycarbonylamino)-4-phenylbutane-1,2-diol