4-methoxy-2-[5,6,7,8-tetrahydro-8-[2-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-1H-indole-5-carbonitrile

Base Information

Chemical Name:4-methoxy-2-[5,6,7,8-tetrahydro-8-[2-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-1H-indole-5-carbonitrile
CAS No.:1420199-43-4
Molecular Formula:C₂₃H₁₈F₃N₅O
Molecular Weight:437.424
Hs Code.:

Synonyms:4-methoxy-2-[5,6,7,8-tetrahydro-8-[2-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-1H-indole-5-carbonitrile

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Chemical Property of 4-methoxy-2-[5,6,7,8-tetrahydro-8-[2-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-1H-indole-5-carbonitrile

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Technology Process of 4-methoxy-2-[5,6,7,8-tetrahydro-8-[2-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-1H-indole-5-carbonitrile

There total 7 articles about 4-methoxy-2-[5,6,7,8-tetrahydro-8-[2-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-1H-indole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 557-21-1
zinc(II) cyanide

: 1123340-52-2
5-chloro-2-(2-trifluoromethyl-phenyl)-pentanomidic acid ethyl ester

: 1420205-70-4
C₁₀H₁₀BrN₃O₂

: 1420199-43-4
4-methoxy-2-[5,6,7,8-tetrahydro-8-[2-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-1H-indole-5-carbonitrile

Guidance literature:: 5-chloro-2-(2-trifluoromethyl-phenyl)-pentanomidic acid ethyl ester; C₁₀H₁₀BrN₃O₂; With 1H-imidazole; In methanol; at 30 ℃;

zinc(II) cyanide; With palladium diacetate; In N,N-dimethyl-formamide; at 135 ℃; for 2.5h; Microwave irradiation;
DOI:10.1016/j.bmcl.2019.05.023

Reference yield: 15.0%

: 557-21-1
zinc(II) cyanide

: 1420206-46-7
C₂₂H₁₈BrF₃N₄O

: 1420199-43-4
4-methoxy-2-[5,6,7,8-tetrahydro-8-[2-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-1H-indole-5-carbonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 - 135 ℃; for 26.5h; Microwave irradiation;

Reference yield:

: 3038-47-9
2-(trifluoromethyl)phenylacetonitrile

: 1420199-43-4
4-methoxy-2-[5,6,7,8-tetrahydro-8-[2-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-1H-indole-5-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / -10 - 0 °C

2.1: ethanol / 0 - 20 °C

3.1: 1H-imidazole / methanol / 30 °C

3.2: 2.5 h / 135 °C / Microwave irradiation

With 1H-imidazole; potassium tert-butylate; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/j.bmcl.2019.05.023