5-chloro-2-(2-trifluoromethyl-phenyl)-pentanomidic acid ethyl ester

Base Information

Chemical Name:5-chloro-2-(2-trifluoromethyl-phenyl)-pentanomidic acid ethyl ester
CAS No.:1123340-52-2
Molecular Formula:C₁₄H₁₇ClF₃NO
Molecular Weight:307.743
Hs Code.:

Synonyms:5-chloro-2-(2-trifluoromethyl-phenyl)-pentanomidic acid ethyl ester

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Chemical Property of 5-chloro-2-(2-trifluoromethyl-phenyl)-pentanomidic acid ethyl ester

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Technology Process of 5-chloro-2-(2-trifluoromethyl-phenyl)-pentanomidic acid ethyl ester

There total 4 articles about 5-chloro-2-(2-trifluoromethyl-phenyl)-pentanomidic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 75-36-5
acetyl chloride

: 5-chloro-2-(2-(trifluoromethyl)phenyl)pentanenitrile

: 1123340-52-2
5-chloro-2-(2-trifluoromethyl-phenyl)-pentanomidic acid ethyl ester

Guidance literature:: In ethanol; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2019.05.023

Reference yield:

: 1213771-65-3
5-chloro-2-(2-trifluoromethyl-phenyl)-pentanoic acid amide

: 368-39-8
triethyloxonium fluoroborate

: 1123340-52-2
5-chloro-2-(2-trifluoromethyl-phenyl)-pentanomidic acid ethyl ester

Guidance literature:: 5-chloro-2-(2-trifluoromethyl-phenyl)-pentanoic acid amide; triethyloxonium fluoroborate; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 3038-47-9
2-(trifluoromethyl)phenylacetonitrile

: 1123340-52-2
5-chloro-2-(2-trifluoromethyl-phenyl)-pentanomidic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / -10 - 0 °C

2: ethanol / 0 - 20 °C

With potassium tert-butylate; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2019.05.023