4-(2-(1-(Ethylamino)-1-oxopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

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Chemical Name:4-(2-(1-(Ethylamino)-1-oxopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid
CAS No.:1332759-65-5
Molecular Formula:C₁₉H₁₉FN₄O₄S
Molecular Weight:418.449
Hs Code.:

Synonyms:4-(2-(1-(Ethylamino)-1-oxopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

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Chemical Property of 4-(2-(1-(Ethylamino)-1-oxopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

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Technology Process of 4-(2-(1-(Ethylamino)-1-oxopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

There total 9 articles about 4-(2-(1-(Ethylamino)-1-oxopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332759-64-4
4-[2-(1-Ethylcarbamoyl-ethoxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

: 1332759-65-5
4-(2-(1-(Ethylamino)-1-oxopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: 4-[2-(1-Ethylcarbamoyl-ethoxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester; With sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃;

With hydrogenchloride; In tetrahydrofuran; methanol; water; Product distribution / selectivity;

Reference yield:

: 832113-96-9
methyl 4-chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate

: 1332759-65-5
4-(2-(1-(Ethylamino)-1-oxopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / 1,4-dioxane / 0.25 h / 140 °C / microwave irradiation

2.1: caesium carbonate / acetonitrile / 2 h / 60 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 0.33 h / 20 °C

4.2: 20 °C

5.1: sodium hydroxide / tetrahydrofuran; methanol / 50 °C

With caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile;

Reference yield:

: 450-91-9
4-fluoro-2-methoxyaniline

: 1332759-65-5
4-(2-(1-(Ethylamino)-1-oxopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane / 100 °C

2.1: boron tribromide / dichloromethane / 20 °C / Cooling with dry ice

2.2: 1.5 h / Cooling with dry ice; Reflux

3.1: caesium carbonate / acetonitrile / 2 h / 60 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 0.33 h / 20 °C

5.2: 20 °C

6.1: sodium hydroxide / tetrahydrofuran; methanol / 50 °C

With hydrogenchloride; boron tribromide; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile;