2S,4R-4-tert-butoxycarbonylmethoxypyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Base Information

Chemical Name:2S,4R-4-tert-butoxycarbonylmethoxypyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester
CAS No.:865436-06-2
Molecular Formula:C₂₀H₂₇NO₇
Molecular Weight:393.437
Hs Code.:

Synonyms:2S,4R-4-tert-butoxycarbonylmethoxypyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

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Chemical Property of 2S,4R-4-tert-butoxycarbonylmethoxypyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

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Technology Process of 2S,4R-4-tert-butoxycarbonylmethoxypyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

There total 1 articles about 2S,4R-4-tert-butoxycarbonylmethoxypyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 64187-48-0
methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate

: 865436-06-2
2S,4R-4-tert-butoxycarbonylmethoxypyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at 55 ℃; for 12h;

Reference yield: 85.0%

: 865436-06-2
2S,4R-4-tert-butoxycarbonylmethoxypyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

: 865436-07-3
2S,4R-4-tert-butoxycarbonylmethoxy-2-hydroxymethylpyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol; at 0 - 10 ℃;
DOI:10.1021/jm070002v

Reference yield:

: 865436-06-2
2S,4R-4-tert-butoxycarbonylmethoxypyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

: C₃₇H₅₇N₃O₉SSi

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / LiCl; NaBH₄ / tetrahydrofuran; ethanol / 0 - 10 °C

2: imidazole / dimethylformamide

3: LiOH / methanol

4: O-benzotriazole-N,N,N',N'-tetramethyluronium*PF₆; diisopropylethylamine / dimethylformamide

With 1H-imidazole; lithium hydroxide; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm070002v