865436-07-3

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 64187-48-0 methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate 
• 865436-06-2 2S,4R-4-tert-butoxycarbonylmethoxypyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 

Downstream Products

• 948092-61-3 2S,4R-2-(tert-butyldimethylsilanyloxymethyl)-4-carboxymethoxypyrrolidine-1-carboxylic acid benzyl ester 
• 948092-62-4 C₃₁H₄₃N₃O₉S 
• 948092-63-5 C₃₁H₄₁N₃O₉S 
• 948092-72-6 2S,4R-{4-carboxymethoxy-2-[(4-methoxypyridin-2-ylamino)-methyl]}pyrrolidine-1-carboxylic acid benzyl ester 
• 865436-09-5 2S,4R-4-carboxymethoxy-2-(pyridin-2-ylaminomethyl)pyrrolidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Design and synthesis of a new class of selective integrin α5β1 antagonists

Starting from the structure of integrin αvβ3 in a complex with a peptidic ligand plus SAR data on nonpeptidic ligands, we derived a new class of integrin α5β1 antagonists (1). Several synthesis strategies were applied to evaluate the chemical space around

NEW COMPOUNDS FOR THE INHIBITION OF ANGIOGENESIS AND USE OF THEREOF

This invention is directed to compounds of structure (I).Particularly this invention is directed to compounds of structure (VIII) wherein the variables are defined as in the description.These compounds are integrin inhibitors and are useful in the treatme