3-[3-(dimethylamino)prop-2-enoyl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

Base Information

• Chemical Name: 3-[3-(dimethylamino)prop-2-enoyl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one
• CAS No.: 1238699-52-9
• Molecular Formula: C₁₆H₁₄F₃N₃O₂
• Molecular Weight: 337.301

Synonyms:3-[3-(dimethylamino)prop-2-enoyl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

Chemical Property of 3-[3-(dimethylamino)prop-2-enoyl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

Chemical Property:

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Technology Process of 3-[3-(dimethylamino)prop-2-enoyl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

There total 1 articles about 3-[3-(dimethylamino)prop-2-enoyl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-{[3-(trifluoromethyl)phenyl]hydrazono}pentane-2,4-dione (58534-61-5) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 3-[3-(dimethylamino)prop-2-enoyl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one (1238699-52-9)

Guidance literature:

at 120 ℃; for 5h;

Reference yield: 47.0%

3-[3-(dimethylamino)prop-2-enoyl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one (1238699-52-9) + benzylhydrazine dihydrochloride (20570-96-1) → 3-(1-Benzyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one (1238698-13-9)

Guidance literature:

With triethylamine; In methanol; for 3h; Reflux;

Reference yield: 44.0%

3-[3-(dimethylamino)prop-2-enoyl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one (1238699-52-9) + cyclopropylmethylhydrazine hydrochloride → 3-[1-(Cyclopropylmethyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one (1238698-10-6)

Guidance literature:

With triethylamine; In methanol; for 2h; Reflux;

upstream raw materials:

3-{[3-(trifluoromethyl)phenyl]hydrazono}pentane-2,4-dione

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

3-(1-Pyridin-2-yl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

3-(1-Benzyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

3-[1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

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