2-(Naphthalen-2-YL)propan-2-amine

Base Information

• Chemical Name: 2-(Naphthalen-2-YL)propan-2-amine
• CAS No.: 90299-04-0
• Molecular Formula: C13H15 N
• Molecular Weight: 185.269
• DSSTox Substance ID: DTXSID40575303
• Nikkaji Number: J816.252B
• Wikidata: Q82464628
• Mol file: 90299-04-0.mol

Synonyms:2-(NAPHTHALEN-2-YL)PROPAN-2-AMINE;90299-04-0;(1-METHYL-1-(NAPHTH-2-YL)ETHYL)AMINE;2-naphthalen-2-ylpropan-2-amine;starbld0019037;SCHEMBL9274665;DTXSID40575303;YVPPUVZWMHWCQE-UHFFFAOYSA-N;AKOS012084916;AB48737;BS-52297;Alpha,alpha-dimethyl-2-naphthalenemethanamine;E76972;EN300-322253;J-519564

Chemical Property of 2-(Naphthalen-2-YL)propan-2-amine

Chemical Property:

• PSA: 26.02000
• LogP: 3.73390
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 185.120449483
• Heavy Atom Count: 14
• Complexity: 197

Purity/Quality:

98%min ^*data from raw suppliers

(1-METHYL-1-(NAPHTH-2-YL)ETHYL)AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C1=CC2=CC=CC=C2C=C1)N

Technology Process of 2-(Naphthalen-2-YL)propan-2-amine

There total 15 articles about 2-(Naphthalen-2-YL)propan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(E)-3-(3,4-dihydro-2-naphthalenyl)-3-methyl-1-phenyl-2-aza-1-butene → 1-methyl-1-naphthalen-2-yl-ethylamine (90299-04-0) + 2-(3,4-dihydro-2-naphthalenyl)-2-methylethylamine (605671-93-0)

Guidance literature:

(E)-3-(3,4-dihydro-2-naphthalenyl)-3-methyl-1-phenyl-2-aza-1-butene; With biphenyl; 9,10-Dicyanoanthracene; In acetonitrile; for 1.5h; Irradiation;

With silica gel; In diethyl ether; hexane;

DOI:10.1021/jo034452g

Reference yield: 77.0%

2-naphthalenecarbonitrile (613-46-7) + methylmagnesium bromide (75-16-1) → 1-methyl-1-naphthalen-2-yl-ethylamine (90299-04-0)

Guidance literature:

2-naphthalenecarbonitrile; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 100 ℃; for 0.166667h; Microwave irradiation;

With titanium(IV) isopropylate; In tetrahydrofuran; diethyl ether; at 50 ℃; for 1h; Microwave irradiation;

DOI:10.1016/j.tetlet.2009.09.178

Reference yield: 68.0%

2-naphthamide (2243-82-5) + dichloromethylcerium (94616-84-9) → 2-naphthalenecarbonitrile (613-46-7) + 1-methyl-1-naphthalen-2-yl-ethylamine (90299-04-0)

Guidance literature:

at -78 - 0 ℃; for 2h; 5.0 equival. MeCeCl₂;

DOI:10.1016/S0040-4039(97)00047-6

upstream raw materials:

2-(1-Azido-1-methyl-ethyl)-naphthalene

2-naphthamide

dichloromethylcerium

ethyl 2-(2-<3,4-dihydronaphthalenyl>)-2-methylpropanoate

Downstream raw materials:

C₂₈H₃₆N₂O₃

C₃₇H₄₅N₃O₃

C₂₃H₂₈N₂O*ClH

N-(2-Hydroxy-ethyl)-2-methyl-N-(1-methyl-1-naphthalen-2-yl-ethyl)-benzamide