5-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile

Base Information

• Chemical Name: 5-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile
• CAS No.: 1259517-64-0
• Molecular Formula: C₁₈H₁₅N₃O₃
• Molecular Weight: 321.335

Synonyms:5-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile

Chemical Property of 5-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile

Chemical Property:

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Technology Process of 5-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile

There total 1 articles about 5-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(1-methylethyl)oxy]-5-(3-{4-[({[2-(trimethylsilyl)ethyl]oxy}methyl)oxy]phenyl}-1,2,4-oxadiazol-5-yl)benzonitrile (1259517-63-9) → 5-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile (1259517-64-0)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; tetrabutyl ammonium fluoride; at 40 ℃;

Reference yield:

ethyl 5-bromovalerate (14660-52-7) + 5-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile (1259517-64-0) → ethyl 5-{[4-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)phenyl]oxy}pentanoate (1259517-65-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield:

Ethyl 4-bromobutyrate (2969-81-5) + 5-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile (1259517-64-0) → ethyl 4-{[4-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)phenyl]oxy}butanoate (1259517-93-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 48h;

upstream raw materials:

2-[(1-methylethyl)oxy]-5-(3-{4-[({[2-(trimethylsilyl)ethyl]oxy}methyl)oxy]phenyl}-1,2,4-oxadiazol-5-yl)benzonitrile

Downstream raw materials:

ethyl 5-{[4-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)phenyl]oxy}pentanoate

ethyl 4-{[4-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)phenyl]oxy}butanoate

ethyl {[4-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)phenyl]oxy}acetate

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