9-(3,4-dimethoxybenzylidene)-4-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-5H-cycloheptapyrimidin-2-ylamine

Base Information

• Chemical Name: 9-(3,4-dimethoxybenzylidene)-4-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-5H-cycloheptapyrimidin-2-ylamine
• CAS No.: 1322199-62-1
• Molecular Formula: C₂₆H₂₉N₃O₄
• Molecular Weight: 447.534
• Mol file: 1322199-62-1.mol

Synonyms:9-(3,4-dimethoxybenzylidene)-4-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-5H-cycloheptapyrimidin-2-ylamine

Chemical Property of 9-(3,4-dimethoxybenzylidene)-4-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-5H-cycloheptapyrimidin-2-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(3,4-dimethoxybenzylidene)-4-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-5H-cycloheptapyrimidin-2-ylamine

There total 2 articles about 9-(3,4-dimethoxybenzylidene)-4-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-5H-cycloheptapyrimidin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2,7-bis-(3,4-dimethoxy-benzylidene)-cycloheptanone (4460-34-8) + guanidine hydrochloride (50-01-1) → 9-(3,4-dimethoxybenzylidene)-4-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-5H-cycloheptapyrimidin-2-ylamine (1322199-62-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 100 ℃;

DOI:10.1016/j.bmcl.2011.06.040

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) + cycloheptanone (502-42-1) → 9-(3,4-dimethoxybenzylidene)-4-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-5H-cycloheptapyrimidin-2-ylamine (1322199-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 0 - 100 °C

With sodium hydride; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; 2: Michael addition;

DOI:10.1016/j.bmcl.2011.06.040

upstream raw materials:

2,7-bis-(3,4-dimethoxy-benzylidene)-cycloheptanone

guanidine hydrochloride

3,4-dimethoxy-benzaldehyde

cycloheptanone