(3S,5S)-3-isopropyl-1,1-dimethoxy-8-methyl-7-methylene-nonan-5-ol

Base Information

• Chemical Name: (3S,5S)-3-isopropyl-1,1-dimethoxy-8-methyl-7-methylene-nonan-5-ol
• CAS No.: 766528-45-4
• Molecular Formula: C₁₆H₃₂O₃
• Molecular Weight: 272.428
• Mol file: 766528-45-4.mol

Synonyms:(3S,5S)-3-isopropyl-1,1-dimethoxy-8-methyl-7-methylene-nonan-5-ol

Chemical Property of (3S,5S)-3-isopropyl-1,1-dimethoxy-8-methyl-7-methylene-nonan-5-ol

Chemical Property:

Purity/Quality:

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Technology Process of (3S,5S)-3-isopropyl-1,1-dimethoxy-8-methyl-7-methylene-nonan-5-ol

There total 1 articles about (3S,5S)-3-isopropyl-1,1-dimethoxy-8-methyl-7-methylene-nonan-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(C5H5)Fe(C5H3(P(C6H5)2)C(O)OCH(CH2C(CH2)CH(CH3)2)CH2CH(CH(CH3)2)CH2CHO) + potassium hydroxide + trimethyl orthoformate (149-73-5) → (Rp)-ortho-diphenylphosphanylferrocene carboxylic acid (149095-48-7,1144039-25-7) + (3S,5S)-3-isopropyl-1,1-dimethoxy-8-methyl-7-methylene-nonan-5-ol (766528-45-4)

Guidance literature:

With TsOH; In ethanol; Fe complex treated with HC(OMe)3 and TsOH in MeOH under heating; heated with KOH in EtOH;

DOI:10.1021/ja0467364

Reference yield: 89.0%

(R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) + (3S,5S)-3-isopropyl-1,1-dimethoxy-8-methyl-7-methylene-nonan-5-ol (766528-45-4) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,3S)-3-(2,2-dimethoxy-ethyl)-4-methyl-1-(3-methyl-2-methylene-butyl)-pentyl ester

Guidance literature:

With pyridine; dmap; In dichloromethane; at 25 ℃; for 3h;

DOI:10.1002/ejoc.200500294

Reference yield: 86.0%

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + (3S,5S)-3-isopropyl-1,1-dimethoxy-8-methyl-7-methylene-nonan-5-ol (766528-45-4) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,3S)-3-(2,2-dimethoxy-ethyl)-4-methyl-1-(3-methyl-2-methylene-butyl)-pentyl ester

Guidance literature:

With pyridine; dmap; In dichloromethane; at 25 ℃; for 3h;

DOI:10.1002/ejoc.200500294

upstream raw materials:

trimethyl orthoformate