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N-(5-chloro-3-(2-cyclopropyl-5-(2-(methylthio)pyrimidin-4-yl)oxazol-4-yl)-2-fluorophenyl)methane sulfonamide

Base Information Edit
  • Chemical Name:N-(5-chloro-3-(2-cyclopropyl-5-(2-(methylthio)pyrimidin-4-yl)oxazol-4-yl)-2-fluorophenyl)methane sulfonamide
  • CAS No.:1353576-49-4
  • Molecular Formula:C18H16ClFN4O3S2
  • Molecular Weight:454.933
  • Hs Code.:
  • Mol file:1353576-49-4.mol
N-(5-chloro-3-(2-cyclopropyl-5-(2-(methylthio)pyrimidin-4-yl)oxazol-4-yl)-2-fluorophenyl)methane sulfonamide

Synonyms:N-(5-chloro-3-(2-cyclopropyl-5-(2-(methylthio)pyrimidin-4-yl)oxazol-4-yl)-2-fluorophenyl)methane sulfonamide

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Chemical Property of N-(5-chloro-3-(2-cyclopropyl-5-(2-(methylthio)pyrimidin-4-yl)oxazol-4-yl)-2-fluorophenyl)methane sulfonamide Edit
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Technology Process of N-(5-chloro-3-(2-cyclopropyl-5-(2-(methylthio)pyrimidin-4-yl)oxazol-4-yl)-2-fluorophenyl)methane sulfonamide

There total 8 articles about N-(5-chloro-3-(2-cyclopropyl-5-(2-(methylthio)pyrimidin-4-yl)oxazol-4-yl)-2-fluorophenyl)methane sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 9 steps
1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / hexane; tetrahydrofuran / 0.83 h / -75 - -65 °C
1.2: 1.25 h / -70 - -65 °C
1.3: -60 - -10 °C / pH 1 - 2
2.1: potassium permanganate / water; tert-butyl alcohol / 2.92 h / 30 - 65 °C
2.2: 0.17 h / 20 °C
2.3: 15 - 25 °C / pH 1
3.1: sulfuric acid / Reflux
4.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 19 h / 0 - 20 °C
5.2: 1 h / 20 °C
6.1: N-Bromosuccinimide / dichloromethane / 2.25 h / -5 - 20 °C
6.2: 20 °C
7.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 1.17 h / 135 °C
8.1: sulfuric acid / ethanol / 20 °C / Reflux
9.1: pyridine / dichloromethane / 20 °C
9.2: 20 °C
9.3: 2 h / 60 °C
With pyridine; 2,2,6,6-tetramethyl-piperidine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium permanganate; N-Bromosuccinimide; n-butyllithium; sulfuric acid; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; bis(dibenzylideneacetone)-palladium(0); In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; tert-butyl alcohol;
Guidance literature:
Multi-step reaction with 7 steps
1.1: sulfuric acid / Reflux
2.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 19 h / 0 - 20 °C
3.2: 1 h / 20 °C
4.1: N-Bromosuccinimide / dichloromethane / 2.25 h / -5 - 20 °C
4.2: 20 °C
5.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 1.17 h / 135 °C
6.1: sulfuric acid / ethanol / 20 °C / Reflux
7.1: pyridine / dichloromethane / 20 °C
7.2: 20 °C
7.3: 2 h / 60 °C
With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N-Bromosuccinimide; sulfuric acid; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; bis(dibenzylideneacetone)-palladium(0); In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
Guidance literature:
Multi-step reaction with 6 steps
1.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 19 h / 0 - 20 °C
2.2: 1 h / 20 °C
3.1: N-Bromosuccinimide / dichloromethane / 2.25 h / -5 - 20 °C
3.2: 20 °C
4.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 1.17 h / 135 °C
5.1: sulfuric acid / ethanol / 20 °C / Reflux
6.1: pyridine / dichloromethane / 20 °C
6.2: 20 °C
6.3: 2 h / 60 °C
With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N-Bromosuccinimide; sulfuric acid; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; bis(dibenzylideneacetone)-palladium(0); In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
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