N-{1-[N-benzyl-N'-(2-hydroxy-ethyl)-hydrazinocarbonyl]-2-hydroxy-propyl}-3-hydroxy-2-methyl-benzamide

Base Information

• Chemical Name: N-{1-[N-benzyl-N'-(2-hydroxy-ethyl)-hydrazinocarbonyl]-2-hydroxy-propyl}-3-hydroxy-2-methyl-benzamide
• CAS No.: 1026062-92-9
• Molecular Formula: C₂₁H₂₇N₃O₅
• Molecular Weight: 401.462

Synonyms:N-{1-[N-benzyl-N'-(2-hydroxy-ethyl)-hydrazinocarbonyl]-2-hydroxy-propyl}-3-hydroxy-2-methyl-benzamide

Chemical Property of N-{1-[N-benzyl-N'-(2-hydroxy-ethyl)-hydrazinocarbonyl]-2-hydroxy-propyl}-3-hydroxy-2-methyl-benzamide

Chemical Property:

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Technology Process of N-{1-[N-benzyl-N'-(2-hydroxy-ethyl)-hydrazinocarbonyl]-2-hydroxy-propyl}-3-hydroxy-2-methyl-benzamide

There total 6 articles about N-{1-[N-benzyl-N'-(2-hydroxy-ethyl)-hydrazinocarbonyl]-2-hydroxy-propyl}-3-hydroxy-2-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{N'-benzyl-N'-[3-hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-butyryl]-hydrazino}-acetic acid ethyl ester (1027203-58-2) → N-{1-[N-benzyl-N'-(2-hydroxy-ethyl)-hydrazinocarbonyl]-2-hydroxy-propyl}-3-hydroxy-2-methyl-benzamide (1026062-92-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2004.11.016

Reference yield:

N'-(2-amino-3-hydroxy-butyryl)-N'-benzyl-hydrazinecarboxylic acid tert-butyl ester → N-{1-[N-benzyl-N'-(2-hydroxy-ethyl)-hydrazinocarbonyl]-2-hydroxy-propyl}-3-hydroxy-2-methyl-benzamide (1026062-92-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: WSC; HOBt / dimethylformamide / 13 h / 0 - 20 °C

2.1: aq. TFA

2.2: Et₃N / dimethylformamide / 1 h / Heating

3.1: LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With lithium aluminium tetrahydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2004.11.016

Reference yield:

N'-benzyl-N'-[3-hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-butyryl]-hydrazinecarboxylic acid tert-butyl ester (1025932-55-1) → N-{1-[N-benzyl-N'-(2-hydroxy-ethyl)-hydrazinocarbonyl]-2-hydroxy-propyl}-3-hydroxy-2-methyl-benzamide (1026062-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. TFA

1.2: Et₃N / dimethylformamide / 1 h / Heating

2.1: LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With lithium aluminium tetrahydride; trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1016/j.ejmech.2004.11.016

upstream raw materials:

{N'-benzyl-N'-[3-hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-butyryl]-hydrazino}-acetic acid ethyl ester

N'-benzyl-N'-[3-hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-butyryl]-hydrazinecarboxylic acid tert-butyl ester

Benzylhydrazine

N'-benzylhydrazinecarboxylic acid tert-butyl ester

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