ethyl 4-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]butanoate

Base Information

Chemical Name:ethyl 4-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]butanoate
CAS No.:676131-97-8
Molecular Formula:C₂₀H₁₇Cl₂NO₅
Molecular Weight:422.265
Hs Code.:

Synonyms:ethyl 4-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]butanoate

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Chemical Property of ethyl 4-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]butanoate

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Technology Process of ethyl 4-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]butanoate

There total 5 articles about ethyl 4-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.38%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 676131-88-7
5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazole

: 676131-97-8
ethyl 4-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]butanoate

Guidance literature:: 5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazole; With sodium ethanolate; In ethanol;

4-chloro-butyric acid ethyl ester; In N,N-dimethyl-formamide; at 80 - 100 ℃;
DOI:10.1002/ardp.200300748

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 676131-97-8
ethyl 4-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: AlCl₃ / dimethylformamide / 0.25 h / 0 - 10 °C

1.2: dimethylformamide / 6 h / 120 °C

2.1: aq. NaOH / ethanol / 7 h / Heating

2.2: acetic acid / H₂O / pH 5.5

3.1: 71 percent / pyridine / 100 °C

4.1: NaOEt / ethanol

4.2: 76.38 percent / dimethylformamide / 80 - 100 °C

With sodium hydroxide; aluminium trichloride; sodium ethanolate; In pyridine; ethanol; N,N-dimethyl-formamide; 1.1: Friedel-Crafts acylation;
DOI:10.1002/ardp.200300748

Reference yield:

: 85052-41-1
2-amino-4-chloro-6-(4-chlorobenzoyl)phenol

: 676131-97-8
ethyl 4-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 71 percent / pyridine / 100 °C

2.1: NaOEt / ethanol

2.2: 76.38 percent / dimethylformamide / 80 - 100 °C

With sodium ethanolate; In pyridine; ethanol;
DOI:10.1002/ardp.200300748