N-(3-(5-fluoro-2-(3-(2-hydroxy-2-methylpropoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Base Information

Chemical Name:N-(3-(5-fluoro-2-(3-(2-hydroxy-2-methylpropoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide
CAS No.:1202757-27-4
Molecular Formula:C₂₃H₂₄FN₅O₃
Molecular Weight:437.474
Hs Code.:

Synonyms:N-(3-(5-fluoro-2-(3-(2-hydroxy-2-methylpropoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

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Chemical Property of N-(3-(5-fluoro-2-(3-(2-hydroxy-2-methylpropoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

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Technology Process of N-(3-(5-fluoro-2-(3-(2-hydroxy-2-methylpropoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

There total 7 articles about N-(3-(5-fluoro-2-(3-(2-hydroxy-2-methylpropoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1202760-26-6
C₂₀H₂₂FN₅O₂

: 814-68-6,25189-84-8
acryloyl chloride

: 1202757-27-4
N-(3-(5-fluoro-2-(3-(2-hydroxy-2-methylpropoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 0 ℃; for 0.75h;

Reference yield:

: 554-84-7
meta-nitrophenol

: 1202757-27-4
N-(3-(5-fluoro-2-(3-(2-hydroxy-2-methylpropoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / ethanol / 10 h / 20 °C

3.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 16 h / 100 °C / Inert atmosphere

4.1: tetrahydrofuran; diethyl ether

5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5.2: 0 °C

6.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.75 h / 0 °C

With hydrogen; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; palladium on activated charcoal; palladium diacetate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 68621-88-5
(3-aminophenyl)carbamic acid tert-butyl ester

: 1202757-27-4
N-(3-(5-fluoro-2-(3-(2-hydroxy-2-methylpropoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

2.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 16 h / 100 °C / Inert atmosphere

3.1: tetrahydrofuran; diethyl ether

4.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

4.2: 0 °C

5.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.75 h / 0 °C

With potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium diacetate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; dichloromethane; toluene;