1,3,5-tris(o-methoxyphenyl)-1,3,5-triazacyclohexane

Base Information

• Chemical Name: 1,3,5-tris(o-methoxyphenyl)-1,3,5-triazacyclohexane
• CAS No.: 85680-36-0
• Molecular Formula: C₂₄H₂₇N₃O₃
• Molecular Weight: 405.497
• Mol file: 85680-36-0.mol

Synonyms:1,3,5-tris(o-methoxyphenyl)-1,3,5-triazacyclohexane

Chemical Property of 1,3,5-tris(o-methoxyphenyl)-1,3,5-triazacyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,5-tris(o-methoxyphenyl)-1,3,5-triazacyclohexane

There total 2 articles about 1,3,5-tris(o-methoxyphenyl)-1,3,5-triazacyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-methoxy-phenylamine (90-04-0) → 1,3,5-tris(o-methoxyphenyl)-1,3,5-triazacyclohexane (85680-36-0)

Guidance literature:

With sodium hydroxide; In xylene; at 45.9 ℃; for 3h;

DOI:10.1107/S0108270194005846

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-methoxy-phenylamine (90-04-0) + 2,2-dihydroperoxyadamantane (229323-97-1) → ((2-hydroperoxyadamantan-2-yl)peroxy)methanol + 1,3,5-tris(o-methoxyphenyl)-1,3,5-triazacyclohexane (85680-36-0)

Guidance literature:

In tetrahydrofuran;

DOI:10.1016/j.tet.2018.01.045

Reference yield: 98.0%

2-phenyl-1-(1-(o-tolyl)-1H-imidazol-2-yl)ethan-1-one + 1,3,5-tris(o-methoxyphenyl)-1,3,5-triazacyclohexane (85680-36-0) → (S)-3-[(2-methoxyphenyl)amino]-2-phenyl-1-[1-(o-tolyl)-1Himidazol-2-yl]propan-1-one

Guidance literature:

With C₅₄H₅₄N₄O₂Rh⁽¹⁺⁾*F₆P^(1-); In dichloromethane; at 25 ℃; for 18h; enantioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201700463

upstream raw materials:

formaldehyd

2-methoxy-phenylamine

2,2-dihydroperoxyadamantane

Downstream raw materials:

2-methoxy-N-methylaniline

(E)-2-methoxybenzaldoxime

(Z)-2-methoxybenzaldehyde oxime