6-[1-oxo-3-[2-N-[[[(phenylmethoxy)carbonyl]amino][(phenylmethoxy)carbonylimino]methyl]piperidinyl]propyl]-2,4-dimethoxypyrimidine

Base Information

Chemical Name:6-[1-oxo-3-[2-N-[[[(phenylmethoxy)carbonyl]amino][(phenylmethoxy)carbonylimino]methyl]piperidinyl]propyl]-2,4-dimethoxypyrimidine
CAS No.:214899-64-6
Molecular Formula:C₃₁H₃₅N₅O₇
Molecular Weight:589.648
Hs Code.:

Synonyms:6-[1-oxo-3-[2-N-[[[(phenylmethoxy)carbonyl]amino][(phenylmethoxy)carbonylimino]methyl]piperidinyl]propyl]-2,4-dimethoxypyrimidine

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Chemical Property of 6-[1-oxo-3-[2-N-[[[(phenylmethoxy)carbonyl]amino][(phenylmethoxy)carbonylimino]methyl]piperidinyl]propyl]-2,4-dimethoxypyrimidine

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Technology Process of 6-[1-oxo-3-[2-N-[[[(phenylmethoxy)carbonyl]amino][(phenylmethoxy)carbonylimino]methyl]piperidinyl]propyl]-2,4-dimethoxypyrimidine

There total 23 articles about 6-[1-oxo-3-[2-N-[[[(phenylmethoxy)carbonyl]amino][(phenylmethoxy)carbonylimino]methyl]piperidinyl]propyl]-2,4-dimethoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: ([(Z)-Benzyloxycarbonylimino]-{2-[3-(2,6-dimethoxy-pyrimidin-4-yl)-3-hydroxy-propyl]-piperidin-1-yl}-methyl)-carbamic acid benzyl ester

: 214899-64-6
6-[1-oxo-3-[2-N-[[[(phenylmethoxy)carbonyl]amino][(phenylmethoxy)carbonylimino]methyl]piperidinyl]propyl]-2,4-dimethoxypyrimidine

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 30h;
DOI:10.1021/ja000647j

Reference yield:

: C₁₅H₁₂BrMgNO₂

: 214899-64-6
6-[1-oxo-3-[2-N-[[[(phenylmethoxy)carbonyl]amino][(phenylmethoxy)carbonylimino]methyl]piperidinyl]propyl]-2,4-dimethoxypyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / EtMgBr / tetrahydrofuran / 2 h / 0 °C

2: 92 percent / hydrogen / Pd/C / methanol; tetrahydrofuran / 20 °C

3: 74 percent / Et₃N; HgCl₂ / dimethylformamide / 2 h / 20 °C

4: 72 percent / Dess-Martin periodinane / CH₂Cl₂ / 30 h / 20 °C

With ethylmagnesium bromide; hydrogen; Dess-Martin periodane; triethylamine; mercury dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Addition / 2: Hydrogenolysis / 3: Substitution / 4: Oxidation;
DOI:10.1021/ja000647j

Reference yield:

: 214899-39-5
phenylmethyl 2-trimethylsilylethynyl-1(2H)-pyridinecarboxylate

: 214899-64-6
6-[1-oxo-3-[2-N-[[[(phenylmethoxy)carbonyl]amino][(phenylmethoxy)carbonylimino]methyl]piperidinyl]propyl]-2,4-dimethoxypyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / K₂CO₃ / methanol / 0.33 h / 20 °C

2: tetrahydrofuran / 0.5 h / 0 °C

3: 62 percent / EtMgBr / tetrahydrofuran / 2 h / 0 °C

4: 92 percent / hydrogen / Pd/C / methanol; tetrahydrofuran / 20 °C

5: 74 percent / Et₃N; HgCl₂ / dimethylformamide / 2 h / 20 °C

6: 72 percent / Dess-Martin periodinane / CH₂Cl₂ / 30 h / 20 °C

With ethylmagnesium bromide; hydrogen; potassium carbonate; Dess-Martin periodane; triethylamine; mercury dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: desilylation / 2: Substitution / 3: Addition / 4: Hydrogenolysis / 5: Substitution / 6: Oxidation;
DOI:10.1021/ja000647j