[3-2H]-(3S)-5-oxo-3-tert-butyldiphenylsilyloxypentanoic acid propyl ester

Base Information

Chemical Name:[3-2H]-(3S)-5-oxo-3-tert-butyldiphenylsilyloxypentanoic acid propyl ester
CAS No.:420838-45-5
Molecular Formula:C₂₄H₃₂O₄Si
Molecular Weight:413.593
Hs Code.:

Synonyms:[3-2H]-(3S)-5-oxo-3-tert-butyldiphenylsilyloxypentanoic acid propyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [3-2H]-(3S)-5-oxo-3-tert-butyldiphenylsilyloxypentanoic acid propyl ester

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Technology Process of [3-2H]-(3S)-5-oxo-3-tert-butyldiphenylsilyloxypentanoic acid propyl ester

There total 7 articles about [3-2H]-(3S)-5-oxo-3-tert-butyldiphenylsilyloxypentanoic acid propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 420838-44-4
[3-2H]-(3S)-5-hydroxy-3-tert-butyldiphenylsilyloxypentanoic acid propyl ester

: 420838-45-5
[3-2H]-(3S)-5-oxo-3-tert-butyldiphenylsilyloxypentanoic acid propyl ester

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; for 3h;
DOI:10.1021/jo016285v

Reference yield:

: 542-05-2
acetonedicarboxylic acid

: 420838-45-5
[3-2H]-(3S)-5-oxo-3-tert-butyldiphenylsilyloxypentanoic acid propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 93 percent / HCl / 20 °C

2.1: 88 percent / Et₃N; D₂ / Raney nickel / propan-1-ol / 18 h

3.1: pig liver eserase / aq. phosphate buffer / 44 h / 4 °C / pH 7 / Enzymatic reaction

4.1: imidazole / CH₂Cl₂ / 20 °C

4.2: 81 percent / Na₂CO₃ / CH₂Cl₂; H₂O

5.1: 88 percent / BH₃ / tetrahydrofuran / 7 h / -18 - 0 °C

6.1: 64 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h

With 1H-imidazole; hydrogenchloride; borane; triethylamine; deuterium; pyridinium chlorochromate; nickel; In tetrahydrofuran; propan-1-ol; phosphate buffer; dichloromethane;
DOI:10.1021/jo016285v

Reference yield:

: 53630-64-1
dipropyl 1,3-acetonedicarboxylate

: 420838-45-5
[3-2H]-(3S)-5-oxo-3-tert-butyldiphenylsilyloxypentanoic acid propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 88 percent / Et₃N; D₂ / Raney nickel / propan-1-ol / 18 h

2.1: pig liver eserase / aq. phosphate buffer / 44 h / 4 °C / pH 7 / Enzymatic reaction

3.1: imidazole / CH₂Cl₂ / 20 °C

3.2: 81 percent / Na₂CO₃ / CH₂Cl₂; H₂O

4.1: 88 percent / BH₃ / tetrahydrofuran / 7 h / -18 - 0 °C

5.1: 64 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h

With 1H-imidazole; borane; triethylamine; deuterium; pyridinium chlorochromate; nickel; In tetrahydrofuran; propan-1-ol; phosphate buffer; dichloromethane;
DOI:10.1021/jo016285v