53630-64-1

Upstream product

• 71-23-8 propan-1-ol 
• 542-05-2 acetonedicarboxylic acid 

Downstream Products

• 1242417-53-3 dipropyl 2-hydroxy-4,6-dimethyl-5-nitrosobenzene-1,3-dicarboxylate 
• 116627-59-9 (4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-iodomethyl-tetrahydro-pyran-2-one 
• 116627-68-0 (4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-iodomethyl-tetrahydro-pyran-2-one 
• 116627-54-4 C₄₀H₅₀O₅Si₂ 
• 116643-38-0 (3S)-3-tert-butyldiphenylsiloxyglutaric acid monopropyl ester 
• 116627-55-5 (3S)-5-hydroxy-3-tert-butyldiphenylsiloxypentanoic acid propyl ester 
• 116627-56-6 (3S)-5-oxo-3-tert-butyldiphenylsiloxypentanoic acid propyl ester 
• 116627-57-7 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-hex-5-enoic acid propyl ester 
• 116627-58-8 (3S)-3-hex-5-enoic acid 
• 421546-82-9 [3,10,11,12-2H]-(3S,5Z,8Z)-3-tert-butyldiphenylsilyloxytetradeca-5,8-dienoic acid propyl ester 
• 420838-43-3 [3-2H]-(3S)-3-tert-butyldiphenylsilyloxyglutaric acid monopropyl ester 
• 420838-44-4 [3-2H]-(3S)-5-hydroxy-3-tert-butyldiphenylsilyloxypentanoic acid propyl ester 
• 420838-45-5 [3-2H]-(3S)-5-oxo-3-tert-butyldiphenylsilyloxypentanoic acid propyl ester 

Relevant academic research and scientific papers

An expedient synthesis of spirooxindoles incorporating 2-amino pyran-3-carbonitrile unit employing dialkyl acetone-1,3-dicarboxylates

Spirooxindoles are a class of molecules possessing significant biological effects such as antiviral, antifungal, antibacterial and anticancer properties. Herein we report a series of spirooxindole molecules having 2-amino pyran-3-carbonitrile and with two ester groups. These molecules were prepared by the reaction of dialkyl acetone-1,3-dicarboxylate and isatilidenes in the presence of triethyl amine.

A convenient method for the synthesis of 3,6-dihydroxybenzene-1,2,4,5-tetracarboxylic acid tetraalkyl esters and a study of their fluorescence properties

A mild, efficient and simple method for the synthesis of 3,6-dihydroxy-1,2,4,5-tetracarboxylic tetraalkyl esters using cerium(IV) ammonium nitrate mediated oxidation of 1,3-acetone dicarboxylates has been developed. The detailed absorption and emission studies of the synthesized compounds reveal that these molecules have appreciable quantum yields and possess large Stokes shift values.

Catalytic hydrogenation of persubstituted p-nitrosophenols

Catalytic hydrogenation of dialkyl 2-hydroxy-4,6-dimethyl-5-nitrosobenzene- 1,3-dicarboxylates over Pd/C gave the corresponding previously unknown dialkyl 5-amino-2-hydroxy-4,6-dimethylbenzene-1,3-dicarboxylates. The first-order rate constants for the hydrogenation process were found to be linearly related to steric constants of the alkyl groups.

Biosynthetic precursors of the lipase inhibitor lipstatin

Three putative intermediates in the biosynthesis of the lipase inhibitor lipstatin were synthesized in stable isotope-labeled form and were added to fermentation cultures of Streptomyces toxytricini. Biosynthetic lipstatin was isolated and analyzed by NMR spectroscopy. [3,10,11,12-2H]-(3S,5Z,8Z)-3-hydroxytetradeca-5,8-dienoic acid (9) was shown to serve as a direct biosynthetic precursor of lipstatin. [7,8-2H2]Hexylmalonate (11) was also incorporated into lipstatin, albeit at a relatively low rate. The leucine moiety of [13C-formyl,15N]-N-formylleucine (10) was diverted to lipstatin under loss of the 13C-labeled formyl residue.

Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates

2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates of the formula, STR1 in which each R is independently H or lower alkyl, are prepared from di(lower alkyl) 1,3-acetone-dicarboxylates.

SYNTHESES OF 4(R)-SILYLOXY-6(S)-IODOMETHYL-TETRAHYDROPYRAN-2-ONE AND ITS ENANTIOMER, BUILDING BLOCKS FOR HMG-COA REDUCTASE INHIBITORS

Optically pure 4(R),6(S)-iodolactone 1 was obtained from α-D-(+)-glucose in 17 steps with 17percent overall yield.Its enantiomer 4(S),6(R)-iodolactone 1' was obtained from acetonedicarboxylic acid in 9 steps in 37percent overall yield and with 70percent e