2-methyl-1-(4-chlorophenyl)-5-(4-i-propylphenyl)-1H-pyrrole

Base Information

• Chemical Name: 2-methyl-1-(4-chlorophenyl)-5-(4-i-propylphenyl)-1H-pyrrole
• CAS No.: 1033281-13-8
• Molecular Formula: C₂₀H₂₀ClN
• Molecular Weight: 309.838
• Mol file: 1033281-13-8.mol

Synonyms:2-methyl-1-(4-chlorophenyl)-5-(4-i-propylphenyl)-1H-pyrrole

Chemical Property of 2-methyl-1-(4-chlorophenyl)-5-(4-i-propylphenyl)-1H-pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-methyl-1-(4-chlorophenyl)-5-(4-i-propylphenyl)-1H-pyrrole

There total 2 articles about 2-methyl-1-(4-chlorophenyl)-5-(4-i-propylphenyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-[4-(i-propyl)phenyl]-pentane-1,4-dione (1033280-93-1) + 4-chloro-aniline (106-47-8) → 2-methyl-1-(4-chlorophenyl)-5-(4-i-propylphenyl)-1H-pyrrole (1033281-13-8)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; at 160 ℃; for 0.5h; under 7757.43 Torr; Microwave irradiation;

DOI:10.1021/jm701560p

Reference yield:

(4-isopropylbenzaldehyde) (122-03-2) → 2-methyl-1-(4-chlorophenyl)-5-(4-i-propylphenyl)-1H-pyrrole (1033281-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide; triethylamine

2: toluene-4-sulfonic acid

With 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide; toluene-4-sulfonic acid; triethylamine; 2: |Paal-Knorr Furan Synthesis;

DOI:10.1016/j.ejmech.2019.05.087

Reference yield: 40.0%

Thiomorpholin (123-90-0) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-methyl-1-(4-chlorophenyl)-5-(4-i-propylphenyl)-1H-pyrrole (1033281-13-8) → 2-methyl-1-(4-chlorophenyl)-3-(thiomorpholin-4-yl)-methyl-5-(4-i-propylphenyl)-1H-pyrrole (1033280-77-1)

Guidance literature:

With acetic acid; In water; acetonitrile; at 20 ℃; for 3h;

DOI:10.1021/jm701560p

upstream raw materials:

1-[4-(i-propyl)phenyl]-pentane-1,4-dione

4-chloro-aniline

(4-isopropylbenzaldehyde)

Downstream raw materials:

2-methyl-1-(4-chlorophenyl)-3-(thiomorpholin-4-yl)-methyl-5-(4-i-propylphenyl)-1H-pyrrole