1-((5-(hydroxymethyl)-4-((4’-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-thioxo-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Base Information

Chemical Name:1-((5-(hydroxymethyl)-4-((4’-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-thioxo-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one
CAS No.:1417528-87-0
Molecular Formula:C₂₅H₂₂F₃N₅O₂S
Molecular Weight:513.543
Hs Code.:

1-((5-(hydroxymethyl)-4-((4’-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-thioxo-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Synonyms:1-((5-(hydroxymethyl)-4-((4’-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-thioxo-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Chemical Property of 1-((5-(hydroxymethyl)-4-((4’-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-thioxo-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Technology Process of 1-((5-(hydroxymethyl)-4-((4’-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-thioxo-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

There total 10 articles about 1-((5-(hydroxymethyl)-4-((4’-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-thioxo-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1417528-85-8
2-thioxo-1-((4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

: 1417528-87-0
1-((5-(hydroxymethyl)-4-((4’-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-thioxo-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: With water; In 1,4-dioxane; for 8h; Reflux;
DOI:10.1016/j.bmcl.2013.01.029

Reference yield:

: 1417528-38-1
(4-(4-bromobenzyl)-5-mercapto-4H-1,2,4-triazol-3-yl)methanol

: 1417528-87-0
1-((5-(hydroxymethyl)-4-((4’-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-thioxo-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid; dihydrogen peroxide / water; dichloromethane / 1.5 h / 20 - 35 °C

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / Reflux

3: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / Reflux

4: hydrogen; palladium 10% on activated carbon / ethanol / 12 h / 20 °C / 760.05 Torr

5: tetraethoxy orthosilicate / ethanol / 5 h / Reflux

6: N,N-dimethyl-formamide / 4 h / 140 °C / Inert atmosphere

7: water / 1,4-dioxane / 8 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetraethoxy orthosilicate; palladium 10% on activated carbon; diphenylphosphoranyl azide; water; hydrogen; dihydrogen peroxide; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.01.029

Reference yield:

: 1417528-40-5
(4-(4-bromobenzyl)-4H-1,2,4-triazol-3-yl)methanol

: 1417528-87-0
1-((5-(hydroxymethyl)-4-((4’-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-thioxo-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / Reflux

2: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / Reflux

3: hydrogen; palladium 10% on activated carbon / ethanol / 12 h / 20 °C / 760.05 Torr

4: tetraethoxy orthosilicate / ethanol / 5 h / Reflux

5: N,N-dimethyl-formamide / 4 h / 140 °C / Inert atmosphere

6: water / 1,4-dioxane / 8 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetraethoxy orthosilicate; palladium 10% on activated carbon; diphenylphosphoranyl azide; water; hydrogen; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.01.029