N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate)

Base Information

• Chemical Name: N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate)
• CAS No.: 132849-84-4
• Molecular Formula: C₃₂H₃₇Cl₂N₆O₈PSi
• Molecular Weight: 763.646

Synonyms:N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate)

Chemical Property of N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate)

There total 4 articles about N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N6-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate) (132849-81-1) → N6-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate) (132849-84-4)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1002/hlca.19910740104

Reference yield:

2,5-dichlorophenyl phosphorodichloridate (53676-18-9) → N6-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate) (132849-84-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,2,4-triazole, pyridine / 30 h / 0 °C

2: 1,2,4-triazole, pyridine / 12 h / Ambient temperature

3: 89 percent / TsOH*H₂O / CH₂Cl₂; methanol / 0.5 h / Ambient temperature

With pyridine; 1,2,4-Triazole; toluene-4-sulfonic acid; In methanol; dichloromethane;

DOI:10.1002/hlca.19910740104

Reference yield:

N6-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine (69504-10-5) → N6-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate) (132849-84-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,2,4-triazole, pyridine / 30 h / 0 °C

2: 1,2,4-triazole, pyridine / 12 h / Ambient temperature

3: 89 percent / TsOH*H₂O / CH₂Cl₂; methanol / 0.5 h / Ambient temperature

With pyridine; 1,2,4-Triazole; toluene-4-sulfonic acid; In methanol; dichloromethane;

DOI:10.1002/hlca.19910740104

upstream raw materials:

N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate)

2,5-dichlorophenyl phosphorodichloridate

N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine

Downstream raw materials:

N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenylyl-<2'-P-(2,5-dichlorophenyl)>->5'>-N⁶-benzoyl-3'-O-<(tert-butyl)dimethylsilyl>adenosine 2'-(2,5-dichlorophenyl 2-cyanoethyl phosphate)

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