trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester
CAS No.:1418003-20-9
Molecular Formula:C₁₉H₂₅N₅O₄
Molecular Weight:387.439
Hs Code.:

Synonyms:trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

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Chemical Property of trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

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Technology Process of trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

There total 1 articles about trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 195314-59-1
tert-butyl (4-aminocyclohexyl)carbamate

: 85967-19-7
4-chloro-3-nitro-[1,5]naphthyridine

: 1418003-20-9
trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 120 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 1418003-20-9
trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

: 1418002-37-5
C₁₇H₂₁N₅O

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium chloride; iron / water / 3.5 h / 80 °C

2.1: triethyloxonium fluoroborate / tetrahydrofuran / 2 h / 20 °C

2.2: 2 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

With triethyloxonium fluoroborate; iron; ammonium chloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1418003-20-9
trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

: 1418002-38-6
C₂₀H₂₄N₆O

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium chloride; iron / water / 3.5 h / 80 °C

2.1: triethyloxonium fluoroborate / tetrahydrofuran / 2 h / 20 °C

2.2: 2 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

4.1: triethylamine / methanol / 18 h / 20 °C

With triethyloxonium fluoroborate; iron; ammonium chloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;