2,3-Dimethoxy-1,7-dimethyl-6-(phenylmethyl)naphthalene

Base Information

Chemical Name:2,3-Dimethoxy-1,7-dimethyl-6-(phenylmethyl)naphthalene
CAS No.:213971-40-5
Molecular Formula:C₂₁H₂₂O₂
Molecular Weight:306.404
Hs Code.:
DSSTox Substance ID:DTXSID801211696

Synonyms:SCHEMBL7194516;DTXSID801211696;2,3-Dimethoxy-1,7-dimethyl-6-(phenylmethyl)naphthalene;213971-40-5

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Chemical Property of 2,3-Dimethoxy-1,7-dimethyl-6-(phenylmethyl)naphthalene

Chemical Property:

XLogP3:5.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:306.161979940
Heavy Atom Count:23
Complexity:363

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC2=C(C(=C(C=C2C=C1CC3=CC=CC=C3)OC)OC)C

Technology Process of 2,3-Dimethoxy-1,7-dimethyl-6-(phenylmethyl)naphthalene

There total 10 articles about 2,3-Dimethoxy-1,7-dimethyl-6-(phenylmethyl)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 213971-21-2
6-Bromo-2,3-dimethoxy-1,7-dimethylnaphthalene

: 213971-40-5
6-Benzyl-2,3-dimethoxy-1,7-dimethylnaphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) ether, hexane, 0 deg C, 15 min, 2.) ether, hexane, RT, 1 h

2: H₂ / 10percent Pd/C / ethanol / 2 h / 3102.9 Torr / Ambient temperature

With n-butyllithium; hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm980334n

Reference yield:

: 213971-61-0
(6,7-Dimethoxy-3,5-dimethyl-naphthalen-2-yl)-phenyl-methanol

: 213971-40-5
6-Benzyl-2,3-dimethoxy-1,7-dimethylnaphthalene

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 2h; under 3102.9 Torr; Yield given; Ambient temperature;
DOI:10.1021/jm980334n

Reference yield:

: 74866-17-4
3,4-dimethoxy-2-methyl-1-bromobenzene

: 213971-40-5
6-Benzyl-2,3-dimethoxy-1,7-dimethylnaphthalene

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) Mg / 1.) THF, reflux, 1 h, 2.) THF, RT, 1 h

2: aq. KOH / ethanol / 3 h / Heating

3: 79 percent / H₂ / 10percent Pd/C / acetic acid / 20 h / 60 °C / 3102.9 Torr

4: 83 percent / polyphosphoric ester / CH₂Cl₂ / 1 h / Heating

5: 1.) sodium borohydride, 2.) 6 M HCl / 1.) 2-propanol, reflux, 1 h, 2.) 2-propanol, reflux, 1 h

6: bromine / CH₂Cl₂

7: DMF / 1 h / 60 - 70 °C

8: 83 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 2 h

9: 1.) n-BuLi / 1.) ether, hexane, 0 deg C, 15 min, 2.) ether, hexane, RT, 1 h

10: H₂ / 10percent Pd/C / ethanol / 2 h / 3102.9 Torr / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; n-butyllithium; polyphosphoric ester; hydrogen; bromine; magnesium; N,N-dimethyl-formamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; benzene;
DOI:10.1021/jm980334n