methyl 2-[4-methoxy-4-(triethylsilylperoxy)cyclohexyl]acetate

Base Information

• Chemical Name: methyl 2-[4-methoxy-4-(triethylsilylperoxy)cyclohexyl]acetate
• CAS No.: 1427281-55-7
• Molecular Formula: C₁₆H₃₂O₅Si
• Molecular Weight: 332.513
• Mol file: 1427281-55-7.mol

Synonyms:methyl 2-[4-methoxy-4-(triethylsilylperoxy)cyclohexyl]acetate

Chemical Property of methyl 2-[4-methoxy-4-(triethylsilylperoxy)cyclohexyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl 2-[4-methoxy-4-(triethylsilylperoxy)cyclohexyl]acetate

There total 2 articles about methyl 2-[4-methoxy-4-(triethylsilylperoxy)cyclohexyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 2-(4-hydroperoxy-4-methoxycyclohexyl)acetate (1427281-70-6) + triethylsilyl trifluoromethyl sulfonate (79271-56-0) → methyl 2-[4-methoxy-4-(triethylsilylperoxy)cyclohexyl]acetate (1427281-55-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h;

DOI:10.1021/jm400004u

Reference yield:

(4-oxo-cyclohexyl)-acetic acid methyl ester (66405-41-2) → methyl 2-[4-methoxy-4-(triethylsilylperoxy)cyclohexyl]acetate (1427281-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; dihydrogen peroxide / 24 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

With dihydrogen peroxide; iodine; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm400004u

Reference yield:

methyl 2-[4-methoxy-4-(triethylsilylperoxy)cyclohexyl]acetate (1427281-55-7) → cis-adamantane-2-spiro-3'8'[[[(2'-amino-2'-methylpropyl)amino]carbonyl]methyl]-1',2'-dioxaspiro[4.5]-decane p-tosylate

Guidance literature:

Multi-step reaction with 4 steps

1.1: tin(IV) chloride / dichloromethane / -78 - -30 °C

2.1: potassium hydroxide; water / ethanol / 20 h / 60 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 h / 20 °C

4.1: chloroform / 4 h / 20 °C

4.2: 40 °C

With water; tin(IV) chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jm400004u

upstream raw materials:

methyl 2-(4-hydroperoxy-4-methoxycyclohexyl)acetate

triethylsilyl trifluoromethyl sulfonate

(4-oxo-cyclohexyl)-acetic acid methyl ester