(4-(4-(4-(bis-(2-(4-hydroxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethyl)amino)butyl)phenyl)butyl)amine

Base Information

• Chemical Name: (4-(4-(4-(bis-(2-(4-hydroxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethyl)amino)butyl)phenyl)butyl)amine
• CAS No.: 960398-45-2
• Molecular Formula: C₃₂H₄₄N₂O₆
• Molecular Weight: 552.711
• Mol file: 960398-45-2.mol

Synonyms:(4-(4-(4-(bis-(2-(4-hydroxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethyl)amino)butyl)phenyl)butyl)amine

Chemical Property of (4-(4-(4-(bis-(2-(4-hydroxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethyl)amino)butyl)phenyl)butyl)amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(4-(4-(bis-(2-(4-hydroxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethyl)amino)butyl)phenyl)butyl)amine

There total 10 articles about (4-(4-(4-(bis-(2-(4-hydroxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethyl)amino)butyl)phenyl)butyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

(4-(4-(4-(bis-(2-(4-benzyloxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethyl)amino)butyl)phenyl)butyl)carbamic acid benzyl ester (960398-44-1) → (4-(4-(4-(bis-(2-(4-hydroxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethyl)amino)butyl)phenyl)butyl)amine (960398-45-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 24h; under 760.051 Torr;

Reference yield:

(4-(4-(4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)but-1-ynyl)phenyl)but-3-ynyl)carbamic acid benzyl ester → (4-(4-(4-(bis-(2-(4-hydroxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethyl)amino)butyl)phenyl)butyl)amine (960398-45-2)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen / palladium(II) hydroxide/carbon / tetrahydrofuran / 24 h / 20 °C / 2327.23 Torr

2: hydrazine / ethanol; dichloromethane / 16 h / Heating / reflux

3: ethanol / 48 h / 60 °C

4: diisobutylaluminium hydride / tetrahydrofuran; hexane / 16 h / 0 - 20 °C

5: hydrogen / palladium 10% on activated carbon / ethanol / 24 h / 20 °C / 760.05 Torr

With hydrogen; diisobutylaluminium hydride; hydrazine; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; dichloromethane;

Reference yield:

(4-(4-(4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyl)phenyl)butyl)carbamic acid benzyl ester (960398-39-4) → (4-(4-(4-(bis-(2-(4-hydroxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethyl)amino)butyl)phenyl)butyl)amine (960398-45-2)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine / ethanol; dichloromethane / 16 h / Heating / reflux

2: ethanol / 48 h / 60 °C

3: diisobutylaluminium hydride / tetrahydrofuran; hexane / 16 h / 0 - 20 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 24 h / 20 °C / 760.05 Torr

With hydrogen; diisobutylaluminium hydride; hydrazine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; dichloromethane;

upstream raw materials:

(4-(4-(4-(bis-(2-(4-benzyloxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethyl)amino)butyl)phenyl)butyl)carbamic acid benzyl ester

(4-(4-(4-aminobutyl)phenyl)butyl)carbamic acid benzyl ester

(4-(4-(4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyl)phenyl)butyl)carbamic acid benzyl ester

C₅₆H₆₂N₂O₁₀