3-(1-(2-chloro-3,6-difluorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

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Chemical Name:3-(1-(2-chloro-3,6-difluorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine
CAS No.:1613148-45-0
Molecular Formula:C₃₉H₃₁ClF₂N₄O
Molecular Weight:645.151
Hs Code.:

Synonyms:3-(1-(2-chloro-3,6-difluorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

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Chemical Property of 3-(1-(2-chloro-3,6-difluorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

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Technology Process of 3-(1-(2-chloro-3,6-difluorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

There total 10 articles about 3-(1-(2-chloro-3,6-difluorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 756503-70-5
5-bromo-3-(1-(2-chloro-3,6-difluorophenyl)ethoxy)pyridin-2-amine

: 1613148-44-9
(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)boronic acid

: 1613148-45-0
3-(1-(2-chloro-3,6-difluorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In water; N,N-dimethyl-formamide; at 90 ℃; Inert atmosphere;

Reference yield:

: 54231-35-5
3-fuoro-2-nitropyridine

: 1613148-45-0
3-(1-(2-chloro-3,6-difluorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil

1.2: 20 °C

2.1: iron; acetic acid / 2.5 h / 100 °C

3.1: N-Bromosuccinimide / acetonitrile / 2.5 h / 0 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,2-dimethoxyethane; water / 12.25 h / 90 °C / Inert atmosphere

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iron; sodium hydride; caesium carbonate; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; water; acetonitrile; mineral oil;

Reference yield:

: 1356330-71-6
5-bromo-2,3-bis(hydroxymethyl)pyridine

: 1613148-45-0
3-(1-(2-chloro-3,6-difluorophenyl)ethoxy)-5-(6-trityl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen bromide / 24 h / 130 °C

1.2: 24 h / 130 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 60 °C

3.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 20 °C / Inert atmosphere

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,2-dimethoxyethane; water / 12.25 h / 90 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen bromide; potassium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;