2,2,2-trifluoro-1-<5-methyl-2-<(2-nitrophenyl)methoxy>phenyl>ethanone

Base Information

• Chemical Name: 2,2,2-trifluoro-1-<5-methyl-2-<(2-nitrophenyl)methoxy>phenyl>ethanone
• CAS No.: 146015-51-2
• Molecular Formula: C₁₆H₁₂F₃NO₄
• Molecular Weight: 339.271
• Mol file: 146015-51-2.mol

Synonyms:2,2,2-trifluoro-1-<5-methyl-2-<(2-nitrophenyl)methoxy>phenyl>ethanone

Chemical Property of 2,2,2-trifluoro-1-<5-methyl-2-<(2-nitrophenyl)methoxy>phenyl>ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trifluoro-1-<5-methyl-2-<(2-nitrophenyl)methoxy>phenyl>ethanone

There total 3 articles about 2,2,2-trifluoro-1-<5-methyl-2-<(2-nitrophenyl)methoxy>phenyl>ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2,2,2-trifluoromethyl-1-(2-hydroxy-5-methylphenyl)ethan-1-one (70978-57-3) + (2-nitrophenyl)methyl methanesulfonate (163915-96-6) → 2,2,2-trifluoro-1-<5-methyl-2-<(2-nitrophenyl)methoxy>phenyl>ethanone (146015-51-2)

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl acetamide; for 18h;

DOI:10.1021/jm00045a016

Reference yield:

2-Nitrobenzyl alcohol (612-25-9) → 2,2,2-trifluoro-1-<5-methyl-2-<(2-nitrophenyl)methoxy>phenyl>ethanone (146015-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / dioxane / 1.5 h / 15 - 25 °C

2: 72 percent / NaI, K₂CO₃ / N,N-dimethyl-acetamide / 18 h

With potassium carbonate; triethylamine; sodium iodide; In 1,4-dioxane; N,N-dimethyl acetamide;

DOI:10.1021/jm00045a016

Reference yield:

→ 2,2,2-trifluoro-1-<5-methyl-2-<(2-nitrophenyl)methoxy>phenyl>ethanone (146015-51-2)

Guidance literature:

upstream raw materials:

2,2,2-trifluoromethyl-1-(2-hydroxy-5-methylphenyl)ethan-1-one

(2-nitrophenyl)methyl methanesulfonate

2-Nitrobenzyl alcohol

Downstream raw materials:

Ethyl 1-[[3-(trifluoromethyl)-2-[2-[[(trifluoromethyl)sulphonyl]amino]phenyl]-5-benzofuranyl]methyl]-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate

1-[[3-(Trifluoromethyl)-2-[2-[[(trifluoromethyl)sulphonyl]amino]phenyl]-5-benzofuranyl]methyl]-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylic acid

ethyl 4-cyclopropyl-2-ethyl-1-<<2-(2-nitrophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-1H-imidazole-5-carboxylate

ethyl 1-<<2-(2-aminophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate