methyl 4-((3E)-4-{2-[(2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoate

Base Information

Chemical Name:methyl 4-((3E)-4-{2-[(2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoate
CAS No.:935253-26-2
Molecular Formula:C₃₄H₃₁ClN₄O₃
Molecular Weight:579.098
Hs Code.:

Synonyms:methyl 4-((3E)-4-{2-[(2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoate

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Chemical Property of methyl 4-((3E)-4-{2-[(2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoate

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Technology Process of methyl 4-((3E)-4-{2-[(2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoate

There total 12 articles about methyl 4-((3E)-4-{2-[(2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.4%

: 935253-25-1
Methyl 4-{(3E)-4-{2-[(2-chlorobenzyl)oxy]phenyl}-2-[2-(4-cyanophenyl)ethyl]but-3-en-1-yl}-benzoate

: 935253-26-2
methyl 4-((3E)-4-{2-[(2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoate

Guidance literature:: With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; at 80 ℃; for 12h;

Reference yield:

: 1-(2-bromoethyl)-4-hydroxymethylbenzene

: 935253-26-2
methyl 4-((3E)-4-{2-[(2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 °C

2.1: formic acid; hydroxylamine hydrochloride / 2 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 0 - 20 °C

4.1: formic acid; triethylamine; triphenylphosphine / palladium diacetate / 1,4-dioxane / 20 - 100 °C

5.1: borane-THF / tetrahydrofuran / -15 °C

6.1: pyridinium chlorochromate / dichloromethane / 5 h / 20 °C

7.1: n-butyllithium / tetrahydrofuran; hexane / 0 - 20 °C

8.1: potassium carbonate / acetonitrile / 12 h / Reflux

9.1: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 12 h / 80 °C

With n-butyllithium; formic acid; borane-THF; trimethylsilylazide; hydroxylamine hydrochloride; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; triethylamine; triphenylphosphine; pyridinium chlorochromate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 72054-56-9
4-(2-bromoethyl)benzonitrile

: 935253-26-2
methyl 4-((3E)-4-{2-[(2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 0 - 20 °C

2.1: formic acid; triethylamine; triphenylphosphine / palladium diacetate / 1,4-dioxane / 20 - 100 °C

3.1: borane-THF / tetrahydrofuran / -15 °C

4.1: pyridinium chlorochromate / dichloromethane / 5 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 0 - 20 °C

6.1: potassium carbonate / acetonitrile / 12 h / Reflux

7.1: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 12 h / 80 °C

With n-butyllithium; formic acid; borane-THF; trimethylsilylazide; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; triethylamine; triphenylphosphine; pyridinium chlorochromate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;