(3R)-3-[(1R)-1-hydroxy-1-(2-methoxy-4,5-methylidenedioxyphenyl)methyl]-2-methylene-4-butanolide

Base Information

Chemical Name:(3R)-3-[(1R)-1-hydroxy-1-(2-methoxy-4,5-methylidenedioxyphenyl)methyl]-2-methylene-4-butanolide
CAS No.:315178-39-3
Molecular Formula:C₁₄H₁₄O₆
Molecular Weight:278.262
Hs Code.:

Synonyms:(3R)-3-[(1R)-1-hydroxy-1-(2-methoxy-4,5-methylidenedioxyphenyl)methyl]-2-methylene-4-butanolide

Suppliers and Price of (3R)-3-[(1R)-1-hydroxy-1-(2-methoxy-4,5-methylidenedioxyphenyl)methyl]-2-methylene-4-butanolide

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Chemical Property of (3R)-3-[(1R)-1-hydroxy-1-(2-methoxy-4,5-methylidenedioxyphenyl)methyl]-2-methylene-4-butanolide

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Technology Process of (3R)-3-[(1R)-1-hydroxy-1-(2-methoxy-4,5-methylidenedioxyphenyl)methyl]-2-methylene-4-butanolide

There total 1 articles about (3R)-3-[(1R)-1-hydroxy-1-(2-methoxy-4,5-methylidenedioxyphenyl)methyl]-2-methylene-4-butanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5780-00-7
2-methoxy-4,5-methylenedioxybenzaldehyde

: 315178-39-3
(3R)-3-[(1R)-1-hydroxy-1-(2-methoxy-4,5-methylidenedioxyphenyl)methyl]-2-methylene-4-butanolide

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -75 °C

1.2: 42 percent / tetrahydrofuran; hexane / 1 h / -75 °C

2.1: 93 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 16 h / 20 °C

3.1: LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

4.1: 7.51 g / pyridine / 17 h / 20 °C

5.1: 91 percent / formic acid / diethyl ether / 1 h / -5 °C

6.1: NaOH / H₂O; ethanol / 20 h / 20 °C

7.1: NaIO₄ / 2-methyl-propan-2-ol; H₂O / 1.5 h / 20 °C

7.2: 1.31 g / Ag₂CO₃/Celite / toluene / 1 h / Heating

8.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -75 °C

8.2: tetrahydrofuran; hexane / 3.5 h / -75 - 0 °C

8.3: 58 percent / methyl iodide / tetrahydrofuran; hexane / 56 h / 20 °C

9.1: 69 percent / trimethylsilylbromide / CH₂Cl₂ / 1 h / -20 °C

With pyridine; sodium hydroxide; sodium periodate; lithium aluminium tetrahydride; formic acid; trimethylsilyl bromide; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1271/bbb.64.2209