1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

Base Information

Chemical Name:1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one
CAS No.:1256782-87-2
Molecular Formula:C₂₁H₂₇F₃N₄O
Molecular Weight:408.467
Hs Code.:

Synonyms:1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

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Chemical Property of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

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Technology Process of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

There total 10 articles about 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 109-01-3
1-methyl-piperazine

: 1-(4-(N-(3-chloropropyl)amino)benzyl)-5-trifluoromethyl-2(1H)-pyridone

: 1256782-87-2
1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

Guidance literature:: In N,N-dimethyl-formamide; at 110 ℃; for 12h;

Reference yield:

: 104-16-5
3-(N-methylpiperazinyl)propyl chloride

: 1256782-84-9
5-trifluoromethyl-(1-(4-amino)benzyl)pyridine-2(1H)-one

: 1256782-87-2
1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

Guidance literature:: potassium iodide; In ethanol; at 110 ℃; Microwave irradiation;

Reference yield:

: 33252-63-0,79894-13-6
5-(trifluoromethyl)-2(1H)-pyridone

: 1256782-87-2
1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dimethyl sulfoxide / 4 h / 85 °C

2.1: hydrogenchloride; iron / ethanol; water / 4 h / Reflux

2.2: pH 10

3.1: potassium iodide / ethanol / 110 °C / Microwave irradiation

With hydrogenchloride; iron; potassium carbonate; potassium iodide; In ethanol; water; dimethyl sulfoxide;