9-[2-amino-2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]-N⁶-benzoyladenine

Base Information

• Chemical Name: 9-[2-amino-2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]-N⁶-benzoyladenine
• CAS No.: 201225-46-9
• Molecular Formula: C₃₈H₃₆N₆O₆
• Molecular Weight: 672.74

Synonyms:9-[2-amino-2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]-N⁶-benzoyladenine

Chemical Property of 9-[2-amino-2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]-N⁶-benzoyladenine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 9-[2-amino-2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]-N⁶-benzoyladenine

There total 12 articles about 9-[2-amino-2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]-N⁶-benzoyladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N6-benzoyladenosine (79154-57-7) → 9-[2-amino-2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]-N6-benzoyladenine (201225-46-9)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / CH₂Cl₂

2: NaN₃ / dimethylformamide

3: aq. HF; pyridine / H₂O

4: pyridine

5: 98 percent / hydrogen / Pd/C / methanol

With pyridine; sodium azide; hydrogen fluoride; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1007/s11172-006-0473-y

Reference yield:

Trifluoro-methanesulfonic acid (2R,3R,3aR,9aR)-2-(6-benzoylamino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester (136923-03-0) → 9-[2-amino-2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]-N6-benzoyladenine (201225-46-9)

Guidance literature:

Multi-step reaction with 4 steps

1: NaN₃ / dimethylformamide

2: aq. HF; pyridine / H₂O

3: pyridine

4: 98 percent / hydrogen / Pd/C / methanol

With pyridine; sodium azide; hydrogen fluoride; hydrogen; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1007/s11172-006-0473-y

Reference yield:

N-benzoyladenosine (4546-55-8) → 9-[2-amino-2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]-N6-benzoyladenine (201225-46-9)

Guidance literature:

Multi-step reaction with 6 steps

1: pyridine / CH₂Cl₂

2: NaN₃ / dimethylformamide

3: aq. HF; pyridine / H₂O

4: pyridine

5: 98 percent / hydrogen / Pd/C / methanol

With pyridine; sodium azide; hydrogen fluoride; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1007/s11172-006-0473-y

upstream raw materials:

4,4'-dimethoxytrityl chloride

N-[9-((2R,3S,4S,5R)-3-Amino-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine

benzoyl chloride

Downstream raw materials:

N-{9-[(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2,2,2-trifluoro-acetylamino)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

9-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-2-methoxalylamino-β-D-arabinofuranosyl]-N⁶-benzoyladenine

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