2-[2-(1H-indol-3-yl)acetyl]-N-phenyl-1-hydrazinecarbothioamide

Base Information

• Chemical Name: 2-[2-(1H-indol-3-yl)acetyl]-N-phenyl-1-hydrazinecarbothioamide
• CAS No.: 153595-90-5
• Molecular Formula: C₁₇H₁₆N₄OS
• Molecular Weight: 324.406
• Mol file: 153595-90-5.mol

Synonyms:2-(2-(1H-indol-3-yl)acetyl)-N-phenylhydrazincarbothioamide

Chemical Property of 2-[2-(1H-indol-3-yl)acetyl]-N-phenyl-1-hydrazinecarbothioamide

Chemical Property:

Purity/Quality:

2-[2-(1H-Indol-3-yl)acetyl]-N-phenyl-1-hydrazinecarbothioamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-[2-(1H-indol-3-yl)acetyl]-N-phenyl-1-hydrazinecarbothioamide

There total 1 articles about 2-[2-(1H-indol-3-yl)acetyl]-N-phenyl-1-hydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1H-indol-3-acetohydrazide (5448-47-5) + phenyl isothiocyanate (103-72-0) → 2-(2-(1H-indol-3-yl)acetyl)-N-phenylhydrazincarbothioamide (153595-90-5)

Guidance literature:

In ethanol; at 80 - 85 ℃;

DOI:10.3109/14756366.2015.1132209

Reference yield: 82.0%

2-(2-(1H-indol-3-yl)acetyl)-N-phenylhydrazincarbothioamide (153595-90-5) → 2-anilino-5-(3-indolylmethyl)-1,3,4-thiadiazole

Guidance literature:

With acetyl chloride; at 20 ℃; for 1h;

Reference yield: 80.0%

2-(2-(1H-indol-3-yl)acetyl)-N-phenylhydrazincarbothioamide (153595-90-5) + methyl iodide (74-88-4) → 1-(3-indolylacetyl)-4-phenyl-S-methylisothiosemicarbazide (153595-98-3)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 10h;

upstream raw materials:

1H-indol-3-acetohydrazide

phenyl isothiocyanate

Downstream raw materials:

5-(3-indolylmethyl)-4-phenyl-1,2,4-thriazoline-3-thione

1-(3-indolylacetyl)-4-phenyl-S-methylisothiosemicarbazide