3,3-(ethylenedioxy)-7β-<(phenylmethoxy)methoxy>-17α-methyl-5α-estran-17β-ol

Base Information

Chemical Name:3,3-(ethylenedioxy)-7β-<(phenylmethoxy)methoxy>-17α-methyl-5α-estran-17β-ol
CAS No.:233769-07-8
Molecular Formula:C₂₉H₄₂O₅
Molecular Weight:470.649
Hs Code.:

Synonyms:3,3-(ethylenedioxy)-7β-<(phenylmethoxy)methoxy>-17α-methyl-5α-estran-17β-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,3-(ethylenedioxy)-7β-<(phenylmethoxy)methoxy>-17α-methyl-5α-estran-17β-ol

Chemical Property:

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Technology Process of 3,3-(ethylenedioxy)-7β-<(phenylmethoxy)methoxy>-17α-methyl-5α-estran-17β-ol

There total 11 articles about 3,3-(ethylenedioxy)-7β-<(phenylmethoxy)methoxy>-17α-methyl-5α-estran-17β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 917-64-6
methyl magnesium iodide

: 233769-05-6
3,3-(ethylenedioxy)-7β-<(phenylmethoxy)methoxy>-5α-estran-17-one

: 233769-07-8
3,3-(ethylenedioxy)-7β-<(phenylmethoxy)methoxy>-17α-methyl-5α-estran-17β-ol

Guidance literature:: In tetrahydrofuran; diethyl ether; for 48h; Ambient temperature;
DOI:10.1021/jm990064o

Reference yield:

: 1425-10-1
19-nortestosterone acetate

: 233769-07-8
3,3-(ethylenedioxy)-7β-<(phenylmethoxy)methoxy>-17α-methyl-5α-estran-17β-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) p-toluenesulfonic acid, 2.) CrO₃, 3,5-dimethylpyrazole / 1.) 83 deg C, 7.5 h, 2.) CH₂Cl₂, -23 deg C, 2.5 h

2: 82 percent / H₂ / 10 percent Pd/C / methanol / 1.5 h / 760 Torr

3: 1.) aq. CeCl₃, NaBH₄, 2.) diisopropylethylamine / 1.) MeOH, THF, RT, 0.5 h, 2.) CH₂Cl₂, RT, 2 h

4: 75 percent / methanolic KOH / 3 h / 50 °C

5: 88 percent / CrO₃, pyridine / CH₂Cl₂ / 0.75 h / Ambient temperature

6: 62 percent / tetrahydrofuran; diethyl ether / 48 h / Ambient temperature

With pyridine; 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; potassium hydroxide; sodium tetrahydroborate; cerium(III) chloride; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm990064o

Reference yield:

: 233768-90-6
3,3-(ethylenedioxy)-7-oxoestra-5-en-17β-yl acetate

: 233769-07-8
3,3-(ethylenedioxy)-7β-<(phenylmethoxy)methoxy>-17α-methyl-5α-estran-17β-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / H₂ / 10 percent Pd/C / methanol / 1.5 h / 760 Torr

2: 1.) aq. CeCl₃, NaBH₄, 2.) diisopropylethylamine / 1.) MeOH, THF, RT, 0.5 h, 2.) CH₂Cl₂, RT, 2 h

3: 75 percent / methanolic KOH / 3 h / 50 °C

4: 88 percent / CrO₃, pyridine / CH₂Cl₂ / 0.75 h / Ambient temperature

5: 62 percent / tetrahydrofuran; diethyl ether / 48 h / Ambient temperature

With pyridine; chromium(VI) oxide; potassium hydroxide; sodium tetrahydroborate; cerium(III) chloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm990064o