(5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-yl)(2-chloro-4-(5-fluoro-2-methylbenzylamino)phenyl)methanone

Base Information

Chemical Name:(5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-yl)(2-chloro-4-(5-fluoro-2-methylbenzylamino)phenyl)methanone
CAS No.:1376615-35-8
Molecular Formula:C₂₇H₂₃ClFN₃O
Molecular Weight:459.951
Hs Code.:

Synonyms:(5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-yl)(2-chloro-4-(5-fluoro-2-methylbenzylamino)phenyl)methanone

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Chemical Property of (5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-yl)(2-chloro-4-(5-fluoro-2-methylbenzylamino)phenyl)methanone

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Technology Process of (5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-yl)(2-chloro-4-(5-fluoro-2-methylbenzylamino)phenyl)methanone

There total 6 articles about (5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-yl)(2-chloro-4-(5-fluoro-2-methylbenzylamino)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 22062-53-9
5-fluoro-2-methylbenzaldehyde

: 168079-19-4
10,11-Dihydro-10-(2-chloro-4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

: 1376615-35-8
(5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-yl)(2-chloro-4-(5-fluoro-2-methylbenzylamino)phenyl)methanone

Guidance literature:: 5-fluoro-2-methylbenzaldehyde; 10,11-Dihydro-10-(2-chloro-4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine; In methanol; for 18h; Reflux;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 4h;

Reference yield:

: 22162-51-2
1-(2-Nitrobenzyl)-2-pyrrolecarboxaldehyde

: 1376615-35-8
(5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-yl)(2-chloro-4-(5-fluoro-2-methylbenzylamino)phenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium on activated charcoal

2.1: triethylamine / dichloromethane

3.1: ammonium chloride; iron / ethanol; water

4.1: methanol / 18 h / Reflux

4.2: 4 h / 20 °C

With hydrogen; iron; ammonium chloride; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water;

Reference yield:

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 1376615-35-8
(5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10(11H)-yl)(2-chloro-4-(5-fluoro-2-methylbenzylamino)phenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide

2.1: hydrogen / palladium on activated charcoal

3.1: triethylamine / dichloromethane

4.1: ammonium chloride; iron / ethanol; water

5.1: methanol / 18 h / Reflux

5.2: 4 h / 20 °C

With hydrogen; iron; sodium hydride; ammonium chloride; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;