(3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(4-thiazolyl)-2-azetidinone

Base Information

• Chemical Name: (3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(4-thiazolyl)-2-azetidinone
• CAS No.: 160237-96-7
• Molecular Formula: C₂₀H₁₈N₂O₃S
• Molecular Weight: 366.441
• Mol file: 160237-96-7.mol

Synonyms:(3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(4-thiazolyl)-2-azetidinone

Chemical Property of (3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(4-thiazolyl)-2-azetidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(4-thiazolyl)-2-azetidinone

There total 1 articles about (3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(4-thiazolyl)-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

thiocarboxamide (115-08-2) + (3R,4R)-3-Benzyloxy-4-(2-bromo-acetyl)-1-(4-methoxy-phenyl)-azetidin-2-one → (3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(4-thiazolyl)-2-azetidinone (160237-96-7)

Guidance literature:

In acetone; for 4h; Heating;

DOI:10.1021/jm00043a005

Reference yield:

(3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(4-thiazolyl)-2-azetidinone (160237-96-7) → (3R,4S)-3-Benzyloxy-4-thiazol-4-yl-azetidin-2-one

Guidance literature:

With ammonium cerium(IV) nitrate; In acetonitrile; for 1h;

DOI:10.1021/jm00043a005

Reference yield:

(3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(4-thiazolyl)-2-azetidinone (160237-96-7) → (3R,4S)-3-Hydroxy-1-(4-methoxy-phenyl)-4-thiazol-4-yl-azetidin-2-one

Guidance literature:

With boron trichloride; In dichloromethane;

DOI:10.1016/j.bmcl.2004.03.109

upstream raw materials:

thiocarboxamide

Downstream raw materials:

(3R,4S)-1-(4-Methoxy-phenyl)-4-thiazol-4-yl-3-triisopropylsilanyloxy-azetidin-2-one

C₄₃H₅₄N₂O₁₃S

C₅₂H₇₄N₂O₁₃SSi