115-08-2Relevant articles and documents
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Londergan et al.
, p. 4456 (1953)
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Characterization of the Simplest Thiolimine: The Higher Energy Tautomer of Thioformamide
Bernhardt, Bastian,Dressler, Friedemann,Eckhardt, André K.,Becker, Jonathan,Schreiner, Peter R.
, p. 6732 - 6739 (2021)
As sulfur-containing organic molecules thioamides and their isomers are conceivable intermediates in prebiotic chemistry, for example, in the formation of amino acids and thiazoles and resemble viable candidates for detection in interstellar media. Here, we report the characterization of parent thioformamide in the solid state via single-crystal X-ray diffraction and its photochemical interconversion to its hitherto unreported higher energy tautomer thiolimine in inert argon and dinitrogen matrices. Upon photogeneration, four conformers of thiolimine form, whose ratio depends on the employed wavelength. One of these conformers interconverts due to quantum mechanical tunneling with a half-life of 30–45 min in both matrix materials at 3 and 20 K. A spontaneous reverse reaction from thiolimine to thioformamide is not observed. To support our experimental findings, we explored the potential energy surface of the system at the AE-CCSD(T)/aug-cc-pCVTZ level of theory and computed tunneling half-lives with the CVT/SCT approach applying DFT methods.
A convenient preparation of thioformamide. Synthesis of thiazole-4-carboxylic acid
Rohaly,Novak,Szantay
, p. 693 - 694 (1999)
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Synthesis of bis(ethylenedithio)dithiadiazafulvalenes (BEDT-DTDAF) and generation of charge-transfer complexes with tetracyanoquinodimethane
Makowiec, Slawomir,Koczan, Wioletta,Rachon, Janusz
, p. 696 - 698 (2008)
The synthesis of bis(ethylenedithio)dithiadiazafulvalenes (BEDT-DTDAFs), in four steps via 4,5-(ethylenedithio)thiazole and 3-alkyl-4,5-(ethylenedithio) thiazolium salts, and the generation of conducting charge-transfer complexes from a new type of dithiadiazafulvalene and tetracyanoquinodimethane are reported. Georg Thieme Verlag Stuttgart.
Thioformamide, and preparation method and application thereof
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Paragraph 0020; 0028-0030, (2020/03/13)
The invention discloses a thioformamide, and a preparation method and an application thereof. Carbon disulfide and formamide which are used as raw materials are reacted under a pressure of 3-5 MPa under the catalytic action of an organic alkali to generate thioformamide, and the thioformamide is rectified and collected after the reaction is finished. The thioformamide prepared in the invention canbe used as an thiabendazole intermediate to synthesize thiabendazole which is applied to the fields of sterilization, corrosion prevention, fresh keeping and the like. The preparation method has theadvantages of simplicity, mild reaction conditions, safety, controllability, low production cost, high yield, no generation of wastewater or toxic gases, and reduction of environmental pollution.
Evaluation of thioamides, thiolactams and thioureas as hydrogen sulfide (H2S)donors for lowering blood pressure
Zaorska, Ewelina,Hutsch, Tomasz,Gawry?-Kopczyńska, Marta,Ostaszewski, Ryszard,Ufnal, Marcin,Koszelewski, Dominik
supporting information, (2019/04/29)
Hydrogen sulfide (H2S)is a biologically important gaseous molecule that exhibits promising protective effects against a variety of pathological processes. For example, it was recognized as a blood pressure lowering agent. Aligned with the need for easily modifiable platforms for the H2S supply, we report here the preparation and the H2S release kinetics from a series of structurally diversified thioamides, thiolactams and thioureas. Three different thionation methods based on the usage of a phosphorus pentasulfide and Lawesson reagent were applied to prepare the target thioamides and thiolactams. Furthermore, obtained H2S donors were evaluated both in in vivo and in vitro studies. The kinetic parameters of the liberating H2S was determined and compared with NaHS and GYY4137 using two different detection technics i.e.; fluorescence labeling 7-azido-4-methyl-2H-chromen-2-one and 5,5‘-dithiobis (2-nitrobenzoic acid), sulfhydryl probe, also known as the Ellman's reagent. We have proved that the amount of releasing H2S from these compounds is controllable through structural modifications. Finally, the present study shows a hypotensive response to an intravenous administration of the developed donors in the anesthetized rats.
