dimethyl 2-(but-2-ynyl)-2-(3-(4-chlorophenyl)-3-oxopropyl)malonate

Base Information

• Chemical Name: dimethyl 2-(but-2-ynyl)-2-(3-(4-chlorophenyl)-3-oxopropyl)malonate
• CAS No.: 1357173-45-5
• Molecular Formula: C₁₈H₁₉ClO₅
• Molecular Weight: 350.799
• Mol file: 1357173-45-5.mol

Synonyms:dimethyl 2-(but-2-ynyl)-2-(3-(4-chlorophenyl)-3-oxopropyl)malonate

Chemical Property of dimethyl 2-(but-2-ynyl)-2-(3-(4-chlorophenyl)-3-oxopropyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of dimethyl 2-(but-2-ynyl)-2-(3-(4-chlorophenyl)-3-oxopropyl)malonate

There total 2 articles about dimethyl 2-(but-2-ynyl)-2-(3-(4-chlorophenyl)-3-oxopropyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3,4'-Dichloropropiophenone (3946-29-0) + dimethyl propargylmalonate (107428-17-1) → dimethyl 2-(but-2-ynyl)-2-(3-(4-chlorophenyl)-3-oxopropyl)malonate (1357173-45-5)

Guidance literature:

dimethyl propargylmalonate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

3,4'-Dichloropropiophenone; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 5h; Inert atmosphere; Reflux;

DOI:10.1021/ja210388g

Reference yield:

p-chlorophenyl vinyl ketone (7448-87-5) + dimethyl propargylmalonate (107428-17-1) → dimethyl 2-(but-2-ynyl)-2-(3-(4-chlorophenyl)-3-oxopropyl)malonate (1357173-45-5)

Guidance literature:

With sodium tetramethoxyborate; In acetonitrile; at 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.6b02599

Reference yield: 80.0%

dimethyl 2-(but-2-ynyl)-2-(3-(4-chlorophenyl)-3-oxopropyl)malonate (1357173-45-5) → dimethyl 2-(but-2-yn-1-yl)-2-(3-(4-chlorophenyl)-3-oxopropyl)malonate-d2

Guidance literature:

dimethyl 2-(but-2-ynyl)-2-(3-(4-chlorophenyl)-3-oxopropyl)malonate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere; Schlenk technique;

With water-d2; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.6b02599

upstream raw materials:

3,4'-Dichloropropiophenone

dimethyl propargylmalonate

p-chlorophenyl vinyl ketone

Downstream raw materials:

(Z)-dimethyl 3-(4-chlorobenzoyl)-4-ethylidenecyclopentane-1,1-dicarboxylate

(Z)-dimethyl 2-(but-2-ynyl)-2-(3-(4-chlorophenyl)-3-(triisopropylsilyloxy)allyl)malonate