(Z)-2'-hydroxy-3'-[N'-(1-indan-5-yl-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazino]biphenyl-3-carboxylic acid

Base Information

Chemical Name:(Z)-2'-hydroxy-3'-[N'-(1-indan-5-yl-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazino]biphenyl-3-carboxylic acid
CAS No.:1176777-42-6
Molecular Formula:C₂₆H₂₂N₄O₄
Molecular Weight:454.485
Hs Code.:

Synonyms:(Z)-2'-hydroxy-3'-[N'-(1-indan-5-yl-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazino]biphenyl-3-carboxylic acid

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Chemical Property of (Z)-2'-hydroxy-3'-[N'-(1-indan-5-yl-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazino]biphenyl-3-carboxylic acid

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Technology Process of (Z)-2'-hydroxy-3'-[N'-(1-indan-5-yl-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazino]biphenyl-3-carboxylic acid

There total 9 articles about (Z)-2'-hydroxy-3'-[N'-(1-indan-5-yl-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazino]biphenyl-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.4%

: 1176777-84-6
1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-1H-pyrazol-5(4H)-one

: 1257792-64-5
3'-amino-2'-hydroxy-biphenyl-3-carboxylic acid hydrobromide

: 1176777-42-6
(Z)-2'-hydroxy-3'-[N'-(1-indan-5-yl-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazino]biphenyl-3-carboxylic acid

Guidance literature:: 1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-1H-pyrazol-5(4H)-one; 3'-amino-2'-hydroxy-biphenyl-3-carboxylic acid hydrobromide; With hydrogenchloride; sodium nitrite; In water; Cooling with ice;

With sodium hydrogencarbonate; In ethanol; water; at 20 ℃; pH=8; Cooling with ice;

Reference yield: 11.4%

: 1176777-84-6
1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-1H-pyrazol-5(4H)-one

: 3'-amino-2'-hydroxybiphenyl-3-carboxylic acid hydrobromide

: 1176777-42-6
(Z)-2'-hydroxy-3'-[N'-(1-indan-5-yl-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazino]biphenyl-3-carboxylic acid

Guidance literature:: With hydrogenchloride; sodium hydrogencarbonate; sodium nitrite; In ethanol; water; at 20 ℃; pH=8; Cooling with ice;

Reference yield:

: 95-56-7
2-hydroxybromobenzene

: 1176777-42-6
(Z)-2'-hydroxy-3'-[N'-(1-indan-5-yl-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazino]biphenyl-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium nitrate; sulfuric acid / water / 2 h / 20 - 25 °C

2.1: potassium carbonate / acetone / 40 h / 70 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 43 h / 105 °C

4.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.33 h / 80 °C

5.1: hydrogen bromide / water / 120 °C

6.1: hydrogenchloride; sodium nitrite / water / Cooling with ice

6.2: 20 °C / pH 8 / Cooling with ice

With hydrogenchloride; sodium nitrate; sulfuric acid; hydrogen bromide; ammonium formate; sodium carbonate; potassium carbonate; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; water; acetone;